Caspase 4 anticorps

N° du produit ABIN2745522

L’anticorps anti-Caspase 4 Monoclonal Rat est utilisé pour la détection de Caspase 4 dans des échantillons de Souris et Rat. Il a été validé pour WB, ELISA, IP et FACS.

Aperçu rapide pour Caspase 4 anticorps (ABIN2745522)

Antigène: Caspase 4 (CASP4) (Caspase 4, Apoptosis-Related Cysteine Peptidase (CASP4))

Reactivité: Souris, Rat

Hôte: Rat

Clonalité: Monoclonal

Conjugué: Cet anticorp Caspase 4 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunoprecipitation (IP), Flow Cytometry (FACS)

Clone: 8A5

Détail du produit anti-Caspase 4 anticorps

Specificité: Recognizes mouse and rat full-length caspase-11 protein. Detects two bands of ~38 kDa and ~43 kDa by Western blot.

Réactivité croisée: Souris, Rat (Rattus)

Pureté: >95 % (SDS-PAGE)

niveau d'endotoxine: <0.1EU/μg purified protein (LAL test, Lonza).

Immunogène: Recombinant mouse caspase-11 (p20 fragment).

Isotype: IgG1

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: In PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Short Term Storage: +4°C
Long Term Storage: -20°C
Stable for at least 1 year after receipt when stored at -20°C.

Date de péremption: 12 months

Détails sur Caspase 4

Antigène: Caspase 4 (CASP4) (Caspase 4, Apoptosis-Related Cysteine Peptidase (CASP4))

Autre désignation: Caspase-11

Sujet: Caspase-11 not only activates caspase-1, that is required for the maturation of proinflammatory cytokines such as interleukin-1 (IL-1) and interleukin-18 (IL-18), but also activates caspase-3, leading to cellular apoptosis under pathological conditions. In most cells, caspase-11 is only expressed upon induction with pro-inflammatory stimuli. Caspase-11 is an essential mediator of endotoxic shock and caspase-11-deficient mice are resistant to endotoxic shock. LPS-induced caspase-11 regulates lymphocyte apoptosis by activating both caspase-3 and caspase-7.

UniProt: P70343

Pathways: Apoptose, Caspase Cascade in Apoptosis, Positive Regulation of Endopeptidase Activity