PARP10 anticorps (AA 1-907)

N° du produit ABIN2745553

Détail du produit anti-PARP10 anticorps

Antigène: PARP10 (Poly (ADP-Ribose) Polymerase Family, Member 10 (PARP10))

Épitope: AA 1-907

Reactivité: Humain

Hôte: Rat

Clonalité: Monoclonal

Conjugué: Cet anticorp PARP10 est non-conjugé

Application: Western Blotting (WB), Immunoprecipitation (IP), Immunocytochemistry (ICC)

Specificité: Recognizes human PARP-10 [ARTD10] with an epitope between aa 256-407, containing the glycine rich (G-rich) region.

Réactivité croisée: Humain

Immunogène: Recombinant human PARP-10 [ARTD10] (aa 1-907) fused to a GST-tag.

Clone: 5H11

Isotype: IgG1

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Cell culture supernatant containing RPMI, 10 % FCS and 0.05 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Short Term Storage: +4°C
Long Term Storage: +4°C
Stable for at least 1 year after receipt when stored at +4°C.

Date de péremption: 12 months

Détails sur PARP10

Antigène: PARP10 (Poly (ADP-Ribose) Polymerase Family, Member 10 (PARP10))

Autre désignation: PARP-10 [ARTD10] (PARP10 Produits)

Synonymes: anticorps ARTD10, anticorps PARP10, anticorps poly(ADP-ribose) polymerase family member 10, anticorps poly (ADP-ribose) polymerase family, member 10, anticorps PARP10, anticorps Parp10

Sujet: PARP-10 is a mono-ADP-ribosyltransferase and was initially identified as an interaction partner of the proto-oncoprotein Myc. PARP-10 possesses ubiquitin-interaction motifs, which are important to inhibit the activation of NF-kappaB and downstream target genes in response to interleukin-1beta and tumor necrosis factor-alpha. PARP-10 mono(ADP-ribosyl)ates (MARylates) NEMO (NF-kappaB essential modulator), which results in reduced NEMO polyubiquitylation and thus decreased NF-kappaB signaling. Overexpression of PARP-10 was shown to lead to apoptosis. PARP-10 knockdown leads to increased cell survival. Additional substrates of PARP-10, such as GSK-3beta were identified and PARP-10-mediated mono(ADP-ribosyl)ation (MARylation) was shown to be involved in regulating multiple processes, including Wnt signaling.

UniProt: Q53GL7