PDE4D anticorps

N° du produit ABIN2747152

Détail du produit anti-PDE4D anticorps

Antigène: PDE4D (phosphodiesterase 4D, cAMP-Specific (PDE4D))

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PDE4D est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunofluorescence (IF), Immunocytochemistry (ICC), Confocal Microscopy (CM)

Purification: Affinity Purified

Immunogène: Synthetic peptide selective for all PDE4D variants.

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.57 μg/μL

Références pour anticorps anti-PDE4D (ABIN2747152)

Massimi, Cardarelli, Galli, Giardi, Ragusa, Panera, Cinque, Cifone, Biagioni, Giorgi: "Increase of Intracellular Cyclic AMP by PDE4 Inhibitors Affects HepG2 Cell Cycle Progression and Survival." dans: Journal of cellular biochemistry, Vol. 118, Issue 6, pp. 1401-1411, (2016) (PubMed).

Petersen, Kristensen, Jeppesen, Grøndahl, Wissing, Macklon, Andersen: "Distribution and function of 3',5'-Cyclic-AMP phosphodiesterases in the human ovary." dans: Molecular and cellular endocrinology, Vol. 403, pp. 10-20, (2015) (PubMed).

Guo, Lin, Zhao, Zhang, Wei, Wang, Wang: "Etazolate abrogates the lipopolysaccharide (LPS)-induced downregulation of the cAMP/pCREB/BDNF signaling, neuroinflammatory response and depressive-like behavior in mice." dans: Neuroscience, Vol. 263, pp. 1-14, (2014) (PubMed).

Zhai, Chang, Wei, Liu, Leblais, Fischmeister, Ji: "Phosphodiesterase types 3 and 4 regulate the phasic contraction of neonatal rat bladder smooth myocytes via distinct mechanisms." dans: Cellular signalling, Vol. 26, Issue 5, pp. 1001-10, (2014) (PubMed).

Dong, Guo, Ye, Hare: "Presynaptic inhibition by α2 receptor/adenylate cyclase/PDE4 complex at retinal rod bipolar synapse." dans: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 34, Issue 28, pp. 9432-40, (2014) (PubMed).

Wang, Zhang, Liu, Zhao, Zhang, Yuan, An, Li, Wang, Qin, Wilson, ODonnell, Zhang, Li: "RNA interference-mediated phosphodiesterase 4D splice variants knock-down in the prefrontal cortex produces antidepressant-like and cognition-enhancing effects." dans: British journal of pharmacology, Vol. 168, Issue 4, pp. 1001-14, (2013) (PubMed).

Michalski, Kanaji, Liu, Nogel, Wang, Basma, Nakanishi, Sato, Gunji, Fahrid, Nelson, Muller, Holz, Magnussen, Rabe, Toews, Rennard: "Attenuation of inhibitory prostaglandin E2 signaling in human lung fibroblasts is mediated by phosphodiesterase 4." dans: American journal of respiratory cell and molecular biology, Vol. 47, Issue 6, pp. 729-37, (2013) (PubMed).

Al-Tawashi, Jung, Liu, Su, Qin: "Protein implicated in nonsyndromic mental retardation regulates protein kinase A (PKA) activity." dans: The Journal of biological chemistry, Vol. 287, Issue 18, pp. 14644-58, (2012) (PubMed).

Abusnina, Alhosin, Keravis, Muller, Fuhrmann, Bronner, Lugnier: "Down-regulation of cyclic nucleotide phosphodiesterase PDE1A is the key event of p73 and UHRF1 deregulation in thymoquinone-induced acute lymphoblastic leukemia cell apoptosis." dans: Cellular signalling, Vol. 23, Issue 1, pp. 152-60, (2011) (PubMed).

Genders, Bradley, Rattigan, Richards: "cGMP phosphodiesterase inhibition improves the vascular and metabolic actions of insulin in skeletal muscle." dans: American journal of physiology. Endocrinology and metabolism, Vol. 301, Issue 2, pp. E342-50, (2011) (PubMed).

Yougbare, Morin, Senouvo, Sirois, Albadine, Lugnier, Rousseau: "NCS 613, a potent and specific PDE4 inhibitor, displays anti-inflammatory effects on human lung tissues." dans: American journal of physiology. Lung cellular and molecular physiology, Vol. 301, Issue 4, pp. L441-50, (2011) (PubMed).

Gregg, Steppan, Gonzalez, Champion, Phan, Nyhan, Shoukas, Hare, Barouch, Berkowitz: "β2-adrenergic receptor-coupled phosphoinositide 3-kinase constrains cAMP-dependent increases in cardiac inotropy through phosphodiesterase 4 activation." dans: Anesthesia and analgesia, Vol. 111, Issue 4, pp. 870-7, (2010) (PubMed).

Zhang, Huang, Masood, Stolinski, Li, Zhang, Dlaboga, Jin, Conti, ODonnell: "Anxiogenic-like behavioral phenotype of mice deficient in phosphodiesterase 4B (PDE4B)." dans: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, Vol. 33, Issue 7, pp. 1611-23, (2008) (PubMed).

Nomura-Furuwatari, Wakitani, Hashimoto, Imai, Ohta, Nakagawa, Nakao, Takayama, Manaka, Takaoka: "Expression profiles of phosphodiesterase 4D splicing variants in osteoblastic cells." dans: Journal of bone and mineral metabolism, Vol. 26, Issue 2, pp. 152-8, (2008) (PubMed).

Fujita, Imaizumi, DSa, Zoghbi, Crescenzo, Hong, Musachio, Gee, Seidel, Green, Pike, Duman, Innis: "In vivo and in vitro measurement of brain phosphodiesterase 4 in rats after antidepressant administration." dans: Synapse (New York, N.Y.), Vol. 61, Issue 2, pp. 78-86, (2007) (PubMed).

Creighton, Zhu, Alexeyev, Stevens: "Spectrin-anchored phosphodiesterase 4D4 restricts cAMP from disrupting microtubules and inducing endothelial cell gap formation." dans: Journal of cell science, Vol. 121, Issue Pt 1, pp. 110-9, (2007) (PubMed).

Baxendale, Fraser: "Mammalian sperm phosphodiesterases and their involvement in receptor-mediated cell signaling important for capacitation." dans: Molecular reproduction and development, Vol. 71, Issue 4, pp. 495-508, (2006) (PubMed).

Dlaboga, Hajjhussein, ODonnell: "Regulation of phosphodiesterase-4 (PDE4) expression in mouse brain by repeated antidepressant treatment: comparison with rolipram." dans: Brain research, Vol. 1096, Issue 1, pp. 104-12, (2006) (PubMed).

Terrin, Di Benedetto, Pertegato, Cheung, Baillie, Lynch, Elvassore, Prinz, Herberg, Houslay, Zaccolo: "PGE(1) stimulation of HEK293 cells generates multiple contiguous domains with different [cAMP]: role of compartmentalized phosphodiesterases." dans: The Journal of cell biology, Vol. 175, Issue 3, pp. 441-51, (2006) (PubMed).

Wang, Deng, Bugaj-Gaweda, Kwan, Gunwaldsen, Leonard, Xin, Hu, Unterbeck, De Vivo: "Cloning and characterization of novel PDE4D isoforms PDE4D6 and PDE4D7." dans: Cellular signalling, Vol. 15, Issue 9, pp. 883-91, (2004) (PubMed).

Détails sur PDE4D

Antigène: PDE4D (phosphodiesterase 4D, cAMP-Specific (PDE4D))

Autre désignation: PDE4D (PDE4D Produits)

Synonymes: anticorps ACRDYS2, anticorps DPDE3, anticorps HSPDE4D, anticorps PDE43, anticorps PDE4DN2, anticorps STRK1, anticorps CMYA2, anticorps MMGL, anticorps 9630011N22Rik, anticorps Dpde3, anticorps 4732458A06Rik, anticorps 9430063L05Rik, anticorps C87016, anticorps D130016K21Rik, anticorps D3Bwg1078e, anticorps Usmg4, anticorps mKIAA0454, anticorps si:dkey-190g11.2, anticorps phosphodiesterase 4D, anticorps phosphodiesterase 4D interacting protein, anticorps phosphodiesterase 4D, cAMP specific, anticorps phosphodiesterase 4D, cAMP-specific, anticorps phosphodiesterase 4D interacting protein (myomegalin), anticorps PDE4D, anticorps PDE4DIP, anticorps pde4d, anticorps Pde4dip, anticorps Pde4d

UniProt: Q07343

Pathways: Cellular Response to Molecule of Bacterial Origin, cAMP Metabolic Process, Myometrial Relaxation and Contraction, Regulation of G-Protein Coupled Receptor Protein Signaling