CD161 anticorps (PE)
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- Antigène Voir toutes CD161 (KLRB1) Anticorps
- CD161 (KLRB1) (Killer Cell Lectin-Like Receptor Subfamily B, Member 1 (KLRB1))
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Reactivité
- Rat
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Hôte
- Souris
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Clonalité
- Monoclonal
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Conjugué
- Cet anticorp CD161 est conjugé à/à la PE
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Application
- Flow Cytometry (FACS)
- Specificité
- The mouse monoclonal antibody 10/78 recognizes CD161, an approximately 30 kDa type II transmembrane C-type lectin receptor, expressed on the plasma membrane of NK cells, dendritic cells, activated monocytes and a subset of T cells as a disulphide-linked homodimer. A common extracellular epitope on rat CD161a and b isoforms is detected.
- Réactivité croisée (Details)
- Rat
- Purification
- Purified antibody is conjugated with R-phycoerythrin (PE) under optimum conditions. Unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.
- Immunogène
- Splenic cells purified from the LEW rat
- Clone
- 10-78
- Isotype
- IgG1 kappa
- Top Product
- Discover our top product KLRB1 Anticorps primaire
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- Indications d'application
- Flow cytometry: Recommended dilution: 1-5 μg/mL.
- Commentaires
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The purified antibody is conjugated with R-Phycoerythrin (PE) under optimum conditions. The conjugate is purified by size-exclusion chromatography.
- Restrictions
- For Research Use only
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- Concentration
- 0.5 mg/mL
- Buffer
- Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- 4 °C
- Stockage commentaire
- Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
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The immunization site of cytokine-secreting tumor cell vaccines influences the trafficking of tumor-specific T lymphocytes and antitumor efficacy against regional tumors." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 173, Issue 10, pp. 6025-32, (2004) (PubMed).
: "Phenotypic characterization of regulatory CD4+CD25+ T cells in rats." dans: International immunology, Vol. 16, Issue 2, pp. 365-75, (2004) (PubMed).
: "CD8 alpha beta T cells are not essential to the pathogenesis of arthritis or colitis in HLA-B27 transgenic rats." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 170, Issue 2, pp. 1099-105, (2003) (PubMed).
: "Evaluation of the hepatic NK cell response during the early phase of Fasciola hepatica infection in rats." dans: Veterinary research, Vol. 33, Issue 3, pp. 327-32, (2002) (PubMed).
: "Central nervous system microglial cell activation and proliferation follows direct interaction with tissue-infiltrating T cell blasts." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 160, Issue 11, pp. 5320-30, (1998) (PubMed).
: "Negative regulation of rat natural killer cell activity by major histocompatibility complex class I recognition." dans: European journal of immunology, Vol. 26, Issue 11, pp. 2582-6, (1997) (PubMed).
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The immunization site of cytokine-secreting tumor cell vaccines influences the trafficking of tumor-specific T lymphocytes and antitumor efficacy against regional tumors." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 173, Issue 10, pp. 6025-32, (2004) (PubMed).
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- Antigène
- CD161 (KLRB1) (Killer Cell Lectin-Like Receptor Subfamily B, Member 1 (KLRB1))
- Autre désignation
- CD161 (KLRB1 Produits)
- Synonymes
- anticorps NKR-P1, anticorps KLRB1, anticorps 4930431A04Rik, anticorps Gm4696, anticorps Klrb1g, anticorps Klrb6, anticorps Ly-55, anticorps Ly55, anticorps NKR-P1G, anticorps Nkrp-1e, anticorps Nkrp1g, anticorps CD161, anticorps CLEC5B, anticorps NKR, anticorps NKR-P1A, anticorps NKRP1A, anticorps hNKR-P1A, anticorps Klrb1d, anticorps Klrb1f, anticorps Nkr-p1e, anticorps killer cell lectin like receptor B1, anticorps killer cell lectin-like receptor subfamily B member 1, anticorps killer cell lectin-like receptor subfamily B, member 1, anticorps KLRB1, anticorps Klrb1
- Sujet
- Killer cell lectin-like receptor subfamily B, memb,CD161, also known as Nkrp1 (natural killer receptor protein 1) or Klrb1 (killer cell lectin-like receptor subfamily b member 1), is a disulphide-linked homodimeric receptor, which is involved in regulation of NK cell and NKT cell function. It is expressed on rat NK cells, subset of T cells, dendritic cells, and activated monocytes. Although human CD161 is expressed as one isoform, the rat CD161 has three isoforms, referred to as CD161a, b, and c. These proteins contain C-terminal C-type lectin extracellular domain, a transmembrane domain, and N-terminal intracellular domain, which contains ITIM motif, such as CD161b, and displays inhibitory function, or does not contain ITIM motif, thus also not the inhibitory function, such as CD161a.,NKRP1A, Klrb
- ID gène
- 689817
- UniProt
- Q0ZUP0
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