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TNFRSF12A anticorps
TNFRSF12A
Reactivité: Humain, Souris
WB, FACS, IHC (fro)
Hôte: Souris
Monoclonal
ITEM-4
unconjugated
N° du produit ABIN2749054
Détail du produit anti-TNFRSF12A anticorps
(cache)
Antigène
Voir toutes TNFRSF12A Anticorps
TNFRSF12A
(Tumor Necrosis Factor Receptor Superfamily, Member 12A (TNFRSF12A))
Reactivité
Toutes les réactivités sur TNFRSF12A Anticorps
Humain, Souris
Hôte
Toutes les hôtes sur TNFRSF12A Anticorps
Souris
Clonalité
Toutes les clonalités sur TNFRSF12A Anticorps
Monoclonal
Conjugué
Tous les conjugués à travers TNFRSF12A Anticorps
Cet anticorp TNFRSF12A est non-conjugé
Application
Tous les applications à travers TNFRSF12A Anticorps.
Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro))
Specificité
The mouse monoclonal antibody ITEM-4 recognizes an extracellular epitope of CD266 / TWEAK R, a TNFR superfamily receptor for CD255 / TWEAK, a TNF-like weak inducer of apoptosis.
Réactivité croisée (Details)
Human, Mouse
Purification
Purified by protein-A affinity chromatography.
Pureté
> 95 % (by SDS-PAGE)
Immunogène
human CD266-transfected P815 cells
Clone
ITEM-4
Isotype
IgG2b
Top Product
Discover our top product TNFRSF12A Anticorps primaire
Alternatives
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anti-Tumor Necrosis Factor Receptor Superfamily, Member 12A (TNFRSF12A) (AA 104-118) antibody
TNFRSF12A
Reactivité: Humain, Souris, Rat, Chien, Lapin, Boeuf (Vache), Cheval, Singe, Roussette (Chauve-souris), Hamster
WB
Hôte: Lapin
Polyclonal
unconjugated
Information d'application
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Indications d'application
Flow cytometry: Recommended dilution: 1-4 μg/mL
Restrictions
For Research Use only
Stockage
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Concentration
1 mg/mL
Buffer
Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
Agent conservateur
Sodium azide
Précaution d'utilisation
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Stock
4 °C
Stockage commentaire
Store at 2-8°C. Do not freeze.
Références pour anticorps anti-TNFRSF12A (ABIN2749054)
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Yoriki, Akashi, Sho, Nomi, Yamato, Hotta, Takayama, Matsumoto, Wakatsuki, Migita, Yagita, Nakajima : "Therapeutic potential of the TWEAK/Fn14 pathway in intractable gastrointestinal cancer. " dans: Experimental and therapeutic medicine , Vol. 2 , Issue 1 , pp. 103-108 , (2012 ) (PubMed ).
Roos, Wicovsky, Müller, Salzmann, Rosenthal, Kalthoff, Trauzold, Seher, Henkler, Kneitz, Wajant : "Soluble and transmembrane TNF-like weak inducer of apoptosis differentially activate the classical and noncanonical NF-kappa B pathway. " dans: Journal of immunology (Baltimore, Md. : 1950) , Vol. 185 , Issue 3 , pp. 1593-605 , (2010 ) (PubMed ).
Nakayama, Ishidoh, Kojima, Harada, Kominami, Okumura, Yagita : "Fibroblast growth factor-inducible 14 mediates multiple pathways of TWEAK-induced cell death. " dans: Journal of immunology (Baltimore, Md. : 1950) , Vol. 170 , Issue 1 , pp. 341-8 , (2002 ) (PubMed ).
Détails sur TNFRSF12A
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Antigène
TNFRSF12A
(Tumor Necrosis Factor Receptor Superfamily, Member 12A (TNFRSF12A))
Autre désignation
CD266 / TWEAK R (TNFRSF12A Produits )
Synonymes
anticorps CD266, anticorps FN14, anticorps TWEAKR, anticorps AI255180, anticorps C87282, anticorps Fn14, anticorps HPIP, anticorps TWEAK-R, anticorps TweakR, anticorps TNF receptor superfamily member 12A, anticorps tumor necrosis factor receptor superfamily, member 12a, anticorps TNFRSF12A, anticorps Tnfrsf12a
Sujet
TNF receptor superfamily member 12A,CD266 / TWEAK R (TNFRSF12A), also known as FN14 (fibroblast growth factor-inducible 14) is a receptor for CD255 / TWEAK, the TNF-like weak inducer of apoptosis. CD266 is expressed on endothelial cells, as well as on some cancer tissues, and plays a role in CD255-induced endothelial cell migration, proliferation, and angiogenesis. The CD255-CD266 interaction, or antibody-mediated triggering of CD266 is also able to induce apoptosis and necrosis in CD266-positive cells (including tumor cells), which might have therapeutic potential.,TWEAKR, FN14, TNFRSF12A
ID gène
51330
UniProt
Q9NP84
Pathways
Apoptose , Regulation of Cell Size
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