CD103 anticorps (APC)
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- Antigène Voir toutes CD103 (ITGAE) Anticorps
- CD103 (ITGAE) (Integrin, alpha E (Antigen CD103, Human Mucosal Lymphocyte Antigen 1, alpha Polypeptide) (ITGAE))
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Reactivité
- Humain, Non-Human Primate
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Hôte
- Souris
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Clonalité
- Monoclonal
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Conjugué
- Cet anticorp CD103 est conjugé à/à la APC
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Application
- Flow Cytometry (FACS)
- Specificité
- The mouse monoclonal antibody Ber-ACT8 recognizes an extracellular epitope of CD103 (alpha E integrin), a type I transmembrane glycoprotein primarily found on intestinal intraepithelial lymphocytes.
- Réactivité croisée (Details)
- Human, Non-Human Primates
- Purification
- Purified antibody is conjugated with activated allophycocyanin (APC) under optimum conditions and unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.
- Immunogène
- HTLV-1 induced human T cell line MAPS16
- Clone
- Ber-ACT8
- Isotype
- IgG1 kappa
- Top Product
- Discover our top product ITGAE Anticorps primaire
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- Indications d'application
- Flow cytometry: The reagent is designed for analysis of human blood cells using 10 μL reagent / 100 μL of whole blood or 106 cells in a suspension. The content of a vial (1 ml) is sufficient for 100 tests.
- Commentaires
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The purified antibody is conjugated with cross-linked Allophycocyanin (APC) under optimum conditions. The conjugate is purified by size-exclusion chromatography and adjusted for direct use. No reconstitution is necessary.
- Restrictions
- For Research Use only
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- Buffer
- Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- 4 °C
- Stockage commentaire
- Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
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Regulatory T cell (Treg) subsets return in patients with refractory lupus following stem cell transplantation, and TGF-beta-producing CD8+ Treg cells are associated with immunological remission of ..." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 183, Issue 10, pp. 6346-58, (2009) (PubMed).
: "Marginal zone B-cell lymphoma: a retrospective immunophenotypic analysis." dans: Cytometry. Part B, Clinical cytometry, Vol. 74, Issue 5, pp. 282-6, (2008) (PubMed).
: "Characterization of CD4+CD25+ natural regulatory T cells in the inflammatory infiltrate of human chronic periodontitis." dans: Journal of leukocyte biology, Vol. 84, Issue 1, pp. 311-8, (2008) (PubMed).
: "Isolation of human small bowel intraepithelial lymphocytes by annexin V-coated magnetic beads." dans: Laboratory investigation; a journal of technical methods and pathology, Vol. 84, Issue 6, pp. 804-9, (2004) (PubMed).
: "Methotrexate markedly reduces the expression of vascular E-selectin, cutaneous lymphocyte-associated antigen and the numbers of mononuclear leucocytes in psoriatic skin." dans: Experimental dermatology, Vol. 13, Issue 7, pp. 426-34, (2004) (PubMed).
: "Flexible migration program regulates gamma delta T-cell involvement in humoral immunity." dans: Blood, Vol. 102, Issue 10, pp. 3693-701, (2003) (PubMed).
: "T cell adhesion and cytolysis of pancreatic cancer cells: a role for E-cadherin in immunotherapy?" dans: British journal of cancer, Vol. 87, Issue 9, pp. 1034-41, (2002) (PubMed).
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Regulatory T cell (Treg) subsets return in patients with refractory lupus following stem cell transplantation, and TGF-beta-producing CD8+ Treg cells are associated with immunological remission of ..." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 183, Issue 10, pp. 6346-58, (2009) (PubMed).
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- Antigène
- CD103 (ITGAE) (Integrin, alpha E (Antigen CD103, Human Mucosal Lymphocyte Antigen 1, alpha Polypeptide) (ITGAE))
- Autre désignation
- CD103 (ITGAE Produits)
- Synonymes
- anticorps A530055J10, anticorps CD103, anticorps aM290, anticorps alpha-E1, anticorps alpha-M290, anticorps HUMINAE, anticorps integrin alpha E, epithelial-associated, anticorps integrin subunit alpha E, anticorps Itgae, anticorps ITGAE
- Sujet
- Integrin subunit alpha E,CD103 / integrin alphaE is an integrin subunit that is expressed on intraepithelial lymphocytes, epithelial dendritic cells, lamina propria-derived dendritic cells, a subpopulation of lamina propria T cells, a small subset of peripheral lymphocytes, namely T reg cells, and on activated and TGF-beta stimulated lymphocytes. CD103 is in mature form cleaved into two disulfide-linked chains (C-terminal 150 kDa chain and N-terminal 25 kDa chain). It heterodimerizes with integrin beta7 subunit to form alphaE/beta7 integrin (mucosal lymphocyte 1 antigen), which through binding E-cadherin mediates homing of lymphocytes to the intestinal epithelium, and, in addition to the role in adhesion, may serve as an accessory molecule for intraepithelial lymphocyte activation.,Integrin alpha E, ITGAE
- ID gène
- 3682
- UniProt
- P38570
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