CD79a anticorps (AA 208-222) (PE)
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- Antigène Voir toutes CD79a (CD79A) Anticorps
- CD79a (CD79A) (B-cell antigen receptor complex-associated protein alpha chain (CD79A))
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Épitope
- AA 208-222
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Reactivité
- Humain, Souris, Rat, Boeuf (Vache), Porc, Poulet, Cobaye, Cheval, Lapin, Chien, Non-Human Primate
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Hôte
- Souris
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Clonalité
- Monoclonal
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Conjugué
- Cet anticorp CD79a est conjugé à/à la PE
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Application
- Flow Cytometry (FACS)
- Specificité
- The mouse monoclonal antibody HM47 reacts with intracellular domain of CD79a (Ig alpha), a 40-45 kDa subunit of B cell antigen-specific receptor (BCR) and its early developmental forms.
- Réactivité croisée (Details)
- Human, Non-Human Primates, Porcine, Mouse, Rat, Bovine, Canine (Dog), Equine (Horse), Guinea pig, Rabbit, Chicken
- Purification
- Purified antibody is conjugated with R-phycoerythrin (PE) under optimum conditions. Unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.
- Immunogène
- Synthetic peptide corresponding to C terminal amino acids 208-222 of human CD79a
- Clone
- HM47
- Isotype
- IgG1 kappa
- Top Product
- Discover our top product CD79A Anticorps primaire
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- Indications d'application
- Flow cytometry: The reagent is designed for analysis of human blood cells using 10 μL reagent / 100 μL of whole blood or 106 cells in a suspension. The content of a vial (1 ml) is sufficient for 100 tests. Intracellular staining.
- Commentaires
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The purified antibody is conjugated with R-Phycoerythrin (PE) under optimum conditions. The conjugate is purified by size-exclusion chromatography and adjusted for direct use. No reconstitution is necessary.
- Restrictions
- For Research Use only
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- Buffer
- Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- 4 °C
- Stockage commentaire
- Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
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C-MYC rearrangements are frequent in aggressive mature B-Cell lymphoma with atypical morphology." dans: International journal of clinical and experimental pathology, Vol. 1, Issue 1, pp. 65-74, (2008) (PubMed).
: "CD79a is heterogeneously expressed in neoplastic and normal myeloid precursors and megakaryocytes in an antibody clone-dependent manner." dans: American journal of clinical pathology, Vol. 128, Issue 2, pp. 306-13, (2007) (PubMed).
: "Immunohistochemical and histochemical stains for differentiating canine cutaneous round cell tumors." dans: Veterinary pathology, Vol. 42, Issue 4, pp. 437-45, (2005) (PubMed).
: "Experimental infection of NOD/SCID mice reconstituted with human CD34+ cells with Epstein-Barr virus." dans: Journal of virology, Vol. 78, Issue 24, pp. 13891-900, (2004) (PubMed).
: "B-cell markers in lymphocyte predominance Hodgkin disease." dans: Archives of pathology & laboratory medicine, Vol. 126, Issue 7, pp. 862-3, (2002) (PubMed).
: "Expression of Ig-beta (CD79b) by chronic lymphocytic leukemia B cells that lack immunoglobulin heavy-chain allelic exclusion." dans: Blood, Vol. 95, Issue 8, pp. 2725-7, (2000) (PubMed).
: "The IgM-associated protein mb-1 as a marker of normal and neoplastic B cells." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 147, Issue 11, pp. 2474-82, (1991) (PubMed).
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C-MYC rearrangements are frequent in aggressive mature B-Cell lymphoma with atypical morphology." dans: International journal of clinical and experimental pathology, Vol. 1, Issue 1, pp. 65-74, (2008) (PubMed).
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- Antigène
- CD79a (CD79A) (B-cell antigen receptor complex-associated protein alpha chain (CD79A))
- Autre désignation
- CD79a (CD79A Produits)
- Synonymes
- anticorps CD79A, anticorps Ig-alpha, anticorps Iga, anticorps Igalpha, anticorps Ly-54, anticorps Ly54, anticorps mb-1, anticorps IGA, anticorps MB-1, anticorps IG-alpha, anticorps CD79a molecule, anticorps CD79A antigen (immunoglobulin-associated alpha), anticorps Cd79a molecule-like, anticorps CD79A, anticorps Cd79a, anticorps Cd79al
- Sujet
- CD79a molecule,CD79a (Ig alpha, MB1) forms disulfide-linked heterodimer with CD79b (Ig beta). They both are transmembrane proteins with extended cytoplasmic domains containing immunoreceptor tyrosine activation motives (ITAMs), and together with cell surface immunoglobulin they constitute B-cell antigen-specific receptor (BCR). CD79a and b are the first components of BCR that are expressed developmentally. They appear on pro-B cells in association with the endoplasmic reticulum chaperone calnexin. Subsequently, in pre-B cells, CD79 heterodimer is associated with lambda5-VpreB surrogate immunoglobulin and later with antigen-specific surface immunoglobulins. At the plasma cell stage, CD79a is present as an intracellular component. CD79a/b complex interacts with Src-family tyrosine kinase Lyn, which phosphorylates its cytoplasmic ITAM motives to form docking sites for downstream signaling.,BCR alpha, Ig-alpha, MB-1, IGA
- ID gène
- 973
- UniProt
- P11912
- Pathways
- BCR Signaling
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