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CD84 anticorps (APC)

CD84 Reactivité: Humain FACS Hôte: Souris Monoclonal CD84-1-21 APC
N° du produit ABIN2749140
  • Antigène Voir toutes CD84 Anticorps
    CD84
    Reactivité
    • 64
    • 25
    • 16
    • 1
    Humain
    Hôte
    • 51
    • 29
    • 3
    Souris
    Clonalité
    • 51
    • 31
    • 1
    Monoclonal
    Conjugué
    • 33
    • 8
    • 7
    • 6
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp CD84 est conjugé à/à la APC
    Application
    • 46
    • 43
    • 25
    • 10
    • 9
    • 5
    • 4
    • 2
    • 2
    • 2
    • 1
    Flow Cytometry (FACS)
    Specificité
    The mouse monoclonal antibody CD84.1.21 recognizes an extracellular epitope of CD84, a single chain cell surface glycoprotein of 64-82 kDa, predominantly expressed B cells, monocytes, platelets and some T cells.
    Réactivité croisée (Details)
    Human
    Purification
    Purified antibody is conjugated with activated allophycocyanin (APC) under optimum conditions and unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.
    Immunogène
    CD84-transfected 300.19 cell line
    Clone
    CD84-1-21
    Isotype
    IgG2a kappa
    Top Product
    Discover our top product CD84 Anticorps primaire
  • Indications d'application
    Flow cytometry: The reagent is designed for analysis of human blood cells using 10 μL reagent / 100 μL of whole blood or 106 cells in a suspension. The content of a vial (1 ml) is sufficient for 100 tests.
    Commentaires

    The purified antibody is conjugated with cross-linked Allophycocyanin (APC) under optimum conditions. The conjugate is purified by size-exclusion chromatography and adjusted for direct use. No reconstitution is necessary.

    Restrictions
    For Research Use only
  • Buffer
    Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C
    Stockage commentaire
    Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
  • Romero, Zapater, Calvo, Kalko, de la Fuente, Tovar, Ockeloen, Pizcueta, Engel: "CD229 (Ly9) lymphocyte cell surface receptor interacts homophilically through its N-terminal domain and relocalizes to the immunological synapse." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 174, Issue 11, pp. 7033-42, (2005) (PubMed).

    Morra, Lu, Poy, Martin, Sayos, Calpe, Gullo, Howie, Rietdijk, Thompson, Coyle, Denny, Yaffe, Engel, Eck, Terhorst: "Structural basis for the interaction of the free SH2 domain EAT-2 with SLAM receptors in hematopoietic cells." dans: The EMBO journal, Vol. 20, Issue 21, pp. 5840-52, (2001) (PubMed).

    Martin, Romero, de la Fuente, Tovar, Zapater, Esplugues, Pizcueta, Bosch, Engel: "CD84 functions as a homophilic adhesion molecule and enhances IFN-gamma secretion: adhesion is mediated by Ig-like domain 1." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 167, Issue 7, pp. 3668-76, (2001) (PubMed).

    Sayós, Martín, Chen, Simarro, Howie, Morra, Engel, Terhorst: "Cell surface receptors Ly-9 and CD84 recruit the X-linked lymphoproliferative disease gene product SAP." dans: Blood, Vol. 97, Issue 12, pp. 3867-74, (2001) (PubMed).

  • Antigène
    CD84
    Autre désignation
    CD84 (CD84 Produits)
    Synonymes
    anticorps RGD1564553, anticorps A130013D22Rik, anticorps CDw84, anticorps SLAMF5, anticorps LY9B, anticorps hCD84, anticorps mCD84, anticorps CD84 molecule, anticorps CD84 antigen, anticorps Cd84, anticorps CD84
    Sujet
    CD84 Molecule,CD84 is a highly glycosylated homophilic receptor of SLAM family. It is expressed on platelets and various types of leukocytes, especially following their activation. Ligation of CD84 leads to its phosphorylation on tyrosine residues within the cytoplasmic tail. These docking sites are recognized by downstream signaling molecules, such as phosphatase SHP-2 and adaptor protein SAP/SH2D1A. The function of CD84 has not been fully elucidated yet. Although predominantly activating receptor, its modulating activity was also demonstrated.,LY9B, SLAMF5
    ID gène
    8832
    UniProt
    Q9UIB8
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