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IKZF2 anticorps (AA 51-107) (PE)

IKZF2 Reactivité: Humain, Souris FACS Hôte: Hamster arménien Monoclonal 22F6 PE
N° du produit ABIN2749147
  • Antigène Voir toutes IKZF2 Anticorps
    IKZF2 (IKAROS Family Zinc Finger 2 (IKZF2))
    Épitope
    • 15
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 51-107
    Reactivité
    • 49
    • 19
    • 10
    • 5
    • 4
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    Humain, Souris
    Hôte
    • 38
    • 7
    • 2
    • 2
    Hamster arménien
    Clonalité
    • 40
    • 9
    Monoclonal
    Conjugué
    • 22
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp IKZF2 est conjugé à/à la PE
    Application
    • 33
    • 13
    • 13
    • 10
    • 9
    • 8
    • 5
    • 5
    • 4
    • 3
    • 2
    Flow Cytometry (FACS)
    Specificité
    The Armenian hamster monoclonal antibody 22F6 recognizes Helios, a transcription factor (intracellular antigen) expressed in some hematopoietic stem cells, and at high levels in thymic-derived regulatory T cells. The epitope is located between amino acids 51 and 107.
    Réactivité croisée (Details)
    Human, Mouse
    Purification
    Purified antibody is conjugated with R-phycoerythrin (PE) under optimum conditions. Unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.
    Immunogène
    Peptide coresponding to the amino acids 51-107 of Helios
    Clone
    22F6
    Isotype
    IgG
    Top Product
    Discover our top product IKZF2 Anticorps primaire
  • Indications d'application
    Flow cytometry: The reagent is designed for analysis of human blood cells using 10 μL reagent / 100 μL of whole blood or 106 cells in a suspension. The content of a vial (1 ml) is sufficient for 100 tests. Intracellular staining.
    Commentaires

    The purified antibody is conjugated with R-Phycoerythrin (PE) under optimum conditions. The conjugate is purified by size-exclusion chromatography and adjusted for direct use. No reconstitution is necessary.

    Restrictions
    For Research Use only
  • Buffer
    Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C
    Stockage commentaire
    Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
  • Blankenhaus, Reitz, Brenz, Eschbach, Hartmann, Haben, Sparwasser, Huehn, Kühl, Feyerabend, Rodewald, Breloer: "Foxp3? regulatory T cells delay expulsion of intestinal nematodes by suppression of IL-9-driven mast cell activation in BALB/c but not in C57BL/6 mice." dans: PLoS pathogens, Vol. 10, Issue 2, pp. e1003913, (2014) (PubMed).

    Atarashi, Tanoue, Oshima, Suda, Nagano, Nishikawa, Fukuda, Saito, Narushima, Hase, Kim, Fritz, Wilmes, Ueha, Matsushima, Ohno, Olle, Sakaguchi, Taniguchi, Morita, Hattori, Honda: "Treg induction by a rationally selected mixture of Clostridia strains from the human microbiota." dans: Nature, Vol. 500, Issue 7461, pp. 232-6, (2013) (PubMed).

    McIver, Melenhorst, Wu, Grim, Ito, Cho, Hensel, Battiwalla, Barrett: "Donor lymphocyte count and thymic activity predict lymphocyte recovery and outcomes after matched-sibling hematopoietic stem cell transplant." dans: Haematologica, Vol. 98, Issue 3, pp. 346-52, (2013) (PubMed).

    Serre, Bénézech, Desanti, Bobat, Toellner, Bird, Chan, Kastner, Cunningham, Maclennan, Mohr: "Helios is associated with CD4 T cells differentiating to T helper 2 and follicular helper T cells in vivo independently of Foxp3 expression." dans: PLoS ONE, Vol. 6, Issue 6, pp. e20731, (2011) (PubMed).

    Pinheiro, Singh, Grant, Appleton, Sacchini, Walker, Chadbourne, Palmer, Armitage-Chan, Thompson, Williamson, Cunningham, Garden: "Phenotypic and functional characterization of a CD4(+) CD25(high) FOXP3(high) regulatory T-cell population in the dog." dans: Immunology, Vol. 132, Issue 1, pp. 111-22, (2010) (PubMed).

  • Antigène
    IKZF2 (IKAROS Family Zinc Finger 2 (IKZF2))
    Autre désignation
    Helios (IKZF2 Produits)
    Synonymes
    anticorps ANF1A2, anticorps HELIOS, anticorps ZNF1A2, anticorps ZNFN1A2, anticorps helios, anticorps znf1a2, anticorps znfn1a1, anticorps znfn1a2, anticorps IKZF2, anticorps MGC159581, anticorps DKFZp469N0319, anticorps A730095J18Rik, anticorps Helios, anticorps Zfpn1a2, anticorps Znfn1a2, anticorps ikzf2, anticorps znfn1a1-a, anticorps IKAROS family zinc finger 2, anticorps si:zfos-1425h8.1, anticorps IKAROS family zinc finger 2 (Helios), anticorps IKAROS family zinc finger 2 L homeolog, anticorps IKZF2, anticorps ikzf2, anticorps Ikzf2, anticorps si:zfos-1425h8.1, anticorps ikzf2.L
    Sujet
    IKAROS family zinc finger 2,Helios, also known as IKZF2 (Ikaros family zinc finger protein 2) is a hematopoietic-specific transcription factor involved in the regulation of lymphocyte development, together with other members of this family, such as Aiolos and Ikaros. Helios forms homo- and heterodimers with these proteins and is thought to function predominantly in early hematopoietic development. Expression of Helios, Aiolos and Ikaros is restricted to cells of the hematopoietic system, whereas other family members, Eos and Pegassus, are more widely expressed. Helios is expressed at early stages of thymocyte development. In mature T cells, Helios has been strongly associated with Treg cells.,ANF1A2, IKZF2
    ID gène
    22807
    UniProt
    Q9UKS7
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