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CD160 anticorps

CD160 Reactivité: Humain FACS, IP Hôte: Souris Monoclonal BY55 unconjugated
N° du produit ABIN2749166
  • Antigène Voir toutes CD160 Anticorps
    CD160
    Reactivité
    • 72
    • 21
    • 16
    • 1
    Humain
    Hôte
    • 55
    • 19
    • 15
    • 1
    Souris
    Clonalité
    • 58
    • 31
    • 1
    Monoclonal
    Conjugué
    • 35
    • 11
    • 7
    • 6
    • 5
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp CD160 est non-conjugé
    Application
    • 60
    • 40
    • 28
    • 13
    • 8
    • 6
    • 5
    • 5
    • 3
    • 2
    • 1
    • 1
    • 1
    Flow Cytometry (FACS), Immunoprecipitation (IP)
    Specificité
    The mouse monoclonal antibody BY55 recognizes an extracellular epitope of CD160, a 27 kDa glycoprotein expressed on NK cells, NK-T cells, intestinal intraepithelial lymphocytes, TCR-gamma/delta T cells and a small population of TCR-alpha/beta T cells. The antibody detects both GPI-anchored and transmembrane form of CD160.
    Réactivité croisée (Details)
    Human
    Purification
    Purified by sequential steps of physicochemical fractionation (differential precipitation and solid-phase chromatography methods).
    Pureté
    > 95 % (by SDS-PAGE)
    Immunogène
    Human NK cell line YT2C2
    Clone
    BY55
    Isotype
    IgM kappa
    Top Product
    Discover our top product CD160 Anticorps primaire
  • Indications d'application
    Flow cytometry: Recommended dilution: 1-4 μg/mL.
    Restrictions
    For Research Use only
  • Concentration
    1 mg/mL
    Buffer
    Tris buffered saline (TBS), pH 8.0, 15 mM sodium azide
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C
    Stockage commentaire
    Store at 2-8°C. Do not freeze.
  • Giustiniani, Bensussan, Marie-Cardine: "Identification and characterization of a transmembrane isoform of CD160 (CD160-TM), a unique activating receptor selectively expressed upon human NK cell activation." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 182, Issue 1, pp. 63-71, (2008) (PubMed).

    Merino, Ramírez, Moreno, Toledo, Fernández, Sánchez-Ibarrola: "BY55/CD160 cannot be considered a cytotoxic marker in cytomegalovirus-specific human CD8(+) T cells." dans: Clinical and experimental immunology, Vol. 149, Issue 1, pp. 87-96, (2007) (PubMed).

  • Antigène
    CD160
    Autre désignation
    CD160 (CD160 Produits)
    Synonymes
    anticorps CD160, anticorps RGD1563598, anticorps BY55, anticorps AU045688, anticorps By55, anticorps NK1, anticorps NK28, anticorps CD160 molecule, anticorps CD160 antigen, anticorps CD160, anticorps Cd160
    Sujet
    CD160 Molecule,CD160 is a cell surface glycoprotein of immunoglobulin superfamily, which functions as a costimulatory receptor expressed mainly on cytotoxic cell populations and recognizing both classical and non-classical MHC class I molecules. It can form disulfide-linked multimers. Down-modulation of CD160 occurs as a consequence of its proteolytic cleavage and the released soluble form was found to impair the MHC-class I specific cytotoxicity of CD8+ T lymphocytes and NK cells. In contrast to GPI-anchored isoform with broader expression among CD160 positive cells, expression of the transmembrane isoform is restricted to NK cells and is activation-dependent.,NK1, NK28
    ID gène
    11126
    UniProt
    O95971
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