TNFRSF4 anticorps (PE)
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- Antigène Voir toutes TNFRSF4 Anticorps
- TNFRSF4 (Tumor Necrosis Factor Receptor Superfamily, Member 4 (TNFRSF4))
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Reactivité
- Humain, Non-Human Primate
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Hôte
- Souris
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Clonalité
- Monoclonal
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Conjugué
- Cet anticorp TNFRSF4 est conjugé à/à la PE
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Application
- Flow Cytometry (FACS)
- Specificité
- The mouse monoclonal antibody Ber-ACT35 (also known as ACT35) recognizes an extracellular epitope of CD134 (TNFRSF4, OX40), an approximately 50 kDa type I transmembrane glycoprotein expressed on activated T cells.
- Réactivité croisée (Details)
- Human, Non-Human Primates
- Purification
- Purified antibody is conjugated with R-phycoerythrin (PE) under optimum conditions. Unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.
- Immunogène
- HTLV 1-transformed HUT-102 cells
- Clone
- Ber-ACT35
- Isotype
- IgG1 kappa
- Top Product
- Discover our top product TNFRSF4 Anticorps primaire
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- Indications d'application
- Flow cytometry: The reagent is designed for analysis of human blood cells using 10 μL reagent / 100 μL of whole blood or 106 cells in a suspension. The content of a vial (1 ml) is sufficient for 100 tests.
- Commentaires
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The purified antibody is conjugated with R-Phycoerythrin (PE) under optimum conditions. The conjugate is purified by size-exclusion chromatography and adjusted for direct use. No reconstitution is necessary.
- Restrictions
- For Research Use only
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- Buffer
- Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- 4 °C
- Stockage commentaire
- Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
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Antibodies targeting human OX40 expand effector T cells and block inducible and natural regulatory T cell function." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 191, Issue 7, pp. 3641-50, (2013) (PubMed).
: "Hodgkin's reed-sternberg cell line (KM-H2) promotes a bidirectional differentiation of CD4+CD25+Foxp3+ T cells and CD4+ cytotoxic T lymphocytes from CD4+ naive T cells." dans: Journal of leukocyte biology, Vol. 82, Issue 3, pp. 576-84, (2007) (PubMed).
: "The effect of anti-human CD134 monoclonal antibody on phytohemagglutinin-induced mRNA expression of perforin in peripheral blood mononuclear cells." dans: Cellular & molecular immunology, Vol. 2, Issue 6, pp. 467-71, (2006) (PubMed).
: "Differential utilization of CD134 as a functional receptor by diverse strains of feline immunodeficiency virus." dans: Journal of virology, Vol. 80, Issue 7, pp. 3386-94, (2006) (PubMed).
: "Coexpression of CD25 and OX40 (CD134) receptors delineates autoreactive T-cells in type 1 diabetes." dans: Diabetes, Vol. 55, Issue 1, pp. 50-60, (2005) (PubMed).
: "Strong and selective glomerular localization of CD134 ligand and TNF receptor-1 in proliferative lupus nephritis." dans: Journal of the American Society of Nephrology : JASN, Vol. 11, Issue 8, pp. 1426-38, (2000) (PubMed).
: "The T-cell activation markers CD30 and OX40/CD134 are expressed in nonoverlapping subsets of peripheral T-cell lymphoma." dans: Blood, Vol. 93, Issue 10, pp. 3487-93, (1999) (PubMed).
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Antibodies targeting human OX40 expand effector T cells and block inducible and natural regulatory T cell function." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 191, Issue 7, pp. 3641-50, (2013) (PubMed).
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- Antigène
- TNFRSF4 (Tumor Necrosis Factor Receptor Superfamily, Member 4 (TNFRSF4))
- Autre désignation
- CD134 (TNFRSF4 Produits)
- Synonymes
- anticorps TNFRSF4, anticorps ACT35, anticorps CD134, anticorps Ly-70, anticorps Ox40, anticorps TXGP1L, anticorps Txgp1, anticorps OX40, anticorps TNF receptor superfamily member 4, anticorps tumor necrosis factor receptor superfamily, member 4, anticorps TNFRSF4, anticorps Tnfrsf4
- Sujet
- TNF receptor superfamily member 4,CD134 (TNFRSF4, also known as OX40) is a type I transmembrane glycoprotein of TNF/NGF receptor family expressed on activated T cells, fibroblasts, and hematopoietic precursors. Binding to its ligand (OX40L, TNFSF4) on antigen presenting cells gives to the T cell costimulatory signal, and this interaction results also in B cell proliferation and influences T cell memory pool. CD134 is upregulated at sites of inflammation, especially in case of multiple sclerosis and psoriatic lesions.,TNFRSF4, OX40, ACT35, IMD16, TXGP1L
- ID gène
- 7293
- UniProt
- P43489
- Pathways
- Production of Molecular Mediator of Immune Response, Cancer Immune Checkpoints
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