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CD70 anticorps

CD70 Reactivité: Humain FACS Hôte: Souris Monoclonal Ki-24 unconjugated
N° du produit ABIN2749184
  • Antigène Voir toutes CD70 Anticorps
    CD70 (CD70 Molecule (CD70))
    Reactivité
    • 97
    • 16
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    Humain
    Hôte
    • 61
    • 36
    • 8
    • 2
    • 1
    Souris
    Clonalité
    • 61
    • 46
    • 1
    Monoclonal
    Conjugué
    • 53
    • 12
    • 11
    • 9
    • 5
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp CD70 est non-conjugé
    Application
    • 50
    • 48
    • 45
    • 37
    • 24
    • 19
    • 17
    • 12
    • 11
    • 9
    • 8
    • 7
    • 5
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    Flow Cytometry (FACS)
    Specificité
    The mouse monoclonal antibody Ki-24 recognizes an extracellular epitope of CD70, an approximately 50 kDa type II transmembrane glycoprotein expressed on activated lymphocytes and some B cell leukemias.
    Réactivité croisée (Details)
    Human
    Purification
    Purified by protein-A affinity chromatography.
    Pureté
    > 95 % (by SDS-PAGE)
    Immunogène
    human L428 cell line
    Clone
    Ki-24
    Isotype
    IgG3 kappa
    Top Product
    Discover our top product CD70 Anticorps primaire
  • Indications d'application
    Flow cytometry: Recommended dilution: 1-5 μg/mL.
    Restrictions
    For Research Use only
  • Concentration
    1 mg/mL
    Buffer
    Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C
    Stockage commentaire
    Store at 2-8°C. Do not freeze.
  • Trebing, El-Mesery, Schäfer, Weisenberger, Siegmund, Silence, Wajant: "CD70-restricted specific activation of TRAILR1 or TRAILR2 using scFv-targeted TRAIL mutants." dans: Cell death & disease, Vol. 5, pp. e1035, (2014) (PubMed).

    Kaufmann, Amariglio, Rosenthal, Hirsch, Many, Rechavi: "Proliferation response of leukemic cells to CD70 ligation oscillates with recurrent remission and relapse in a low-grade lymphoma." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 175, Issue 10, pp. 6940-7, (2005) (PubMed).

    Israel, Pickles, Segal, Gerard, Kenney: "Enhancement of adenovirus vector entry into CD70-positive B-cell Lines by using a bispecific CD70-adenovirus fiber antibody." dans: Journal of virology, Vol. 75, Issue 11, pp. 5215-21, (2001) (PubMed).

  • Antigène
    CD70 (CD70 Molecule (CD70))
    Autre désignation
    CD70 (CD70 Produits)
    Sujet
    CD70 Molecule,CD70, also known as TNFSF7 or CD27L, is a 50 kDa type II transmembrane glycoprotein of the TNF superfamily. It is expressed mainly on activated lymphocytes, including NK cells, and forms trimeric structure. CD70 plays a role in T-cell activation, proliferation and differentiation, in enhancing the generation of cytolytic T cells, and in long-term maintenance of T cell memory. It is also involved in B cell differentiation induced by activated plasmacytoid dendritic cells, which also express CD70.,CD27L, TNFSF7, CD27 ligand, TNLG8A
    ID gène
    970
    UniProt
    P32970
    Pathways
    Cancer Immune Checkpoints
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