FAS anticorps

N° du produit ABIN2749190

Détail du produit anti-FAS anticorps

Antigène: FAS (TNF Receptor Superfamily, Member 6 (FAS))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp FAS est non-conjugé

Application: Flow Cytometry (FACS), Functional Studies (Func)

Specificité: The mouse monoclonal antibody EOS9.1 recognizes an extracellular epitope of CD95 (Fas/APO-1), a 46 kDa glycoprotein of the tumour necrosis factor/nerve growth factor (TNF/NGF) receptor superfamily, expressed on a variety of normal and neoplastic cells.

Réactivité croisée (Details): Human

Purification: Purified by sequential steps of physicochemical fractionation (differential precipitation and solid-phase chromatography methods).

Pureté: > 95 % (by SDS-PAGE)

niveau d'endotoxine: Endotoxin level is less than 0.01 EU/µg of the protein, as determined by the LAL test.

Immunogène: P815 cells transfected with human CD95

Clone: EOS9-1

Isotype: IgM kappa

Information d'application

Indications d'application: Functional application: In vitro induction of apoptosis.
Flow cytometry: Recommended dilution: 2-6 μg/mL.

Restrictions: For Research Use only

Stockage

Concentration: 1 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.4

Agent conservateur: Azide free

Stock: 4 °C

Stockage commentaire: Store at 2-8°C. Do not freeze.

Références pour anticorps anti-FAS (ABIN2749190)

Matsuoka, Kim, McDonough, Bascug, Warshauer, Koreth, Cutler, Ho, Alyea, Antin, Soiffer, Ritz: "Altered regulatory T cell homeostasis in patients with CD4+ lymphopenia following allogeneic hematopoietic stem cell transplantation." dans: The Journal of clinical investigation, Vol. 120, Issue 5, pp. 1479-93, (2010) (PubMed).

Kasper, Konze, Kern, Stippel: "CD95 and TNFα-induced apoptosis in liver metastases of colorectal carcinoma." dans: In vivo (Athens, Greece), Vol. 24, Issue 5, pp. 653-7, (2010) (PubMed).

Conejo-Garcia, Benencia, Courreges, Gimotty, Khang, Buckanovich, Frauwirth, Zhang, Katsaros, Thompson, Levine, Coukos: "Ovarian carcinoma expresses the NKG2D ligand Letal and promotes the survival and expansion of CD28- antitumor T cells." dans: Cancer research, Vol. 64, Issue 6, pp. 2175-82, (2004) (PubMed).

Desbarats, Birge, Mimouni-Rongy, Weinstein, Palerme, Newell: "Fas engagement induces neurite growth through ERK activation and p35 upregulation." dans: Nature cell biology, Vol. 5, Issue 2, pp. 118-25, (2003) (PubMed).

Détails sur FAS

Antigène: FAS (TNF Receptor Superfamily, Member 6 (FAS))

Autre désignation: CD95 / Fas (FAS Produits)

Synonymes: anticorps ALPS1A, anticorps APO-1, anticorps APT1, anticorps CD95, anticorps FAS1, anticorps FASTM, anticorps TNFRSF6, anticorps AI196731, anticorps APO1, anticorps TNFR6, anticorps Tnfrsf6, anticorps lpr, anticorps Fas cell surface death receptor, anticorps Fas (TNF receptor superfamily member 6), anticorps FAS, anticorps Fas, anticorps fas

Sujet: Fas cell surface death receptor,CD95 (Fas, APO-1), a 46 kDa transmembrane glycoprotein, is a cell death receptor of the TNFR superfamily. Stimulation of CD95 results in aggregation of its intracellular death domains, formation of the death-inducing signaling complex (DISC) and activation of caspases. In type I cells caspase 3 is activated by high amounts of caspase 8 generated at the DISC, in type II cells low concentration of caspase 8 activates pathway leading to the release of cytochrome c from mitochondria and activation of caspase 3 by cytochom c. Besides its roles in induction of apoptosis, Fas also triggers pro-inflammatory cytokine responses.,FAS1, APT1, APO-1, FASTM, ALPS1A, TNFRSF6

ID gène: 355

UniProt: P25445

Pathways: Signalisation p53, Apoptose, Production of Molecular Mediator of Immune Response, Positive Regulation of Endopeptidase Activity