EDAR anticorps (Middle Region)

N° du produit ABIN2773948

Détail du produit anti-EDAR anticorps

Antigène: EDAR (Ectodysplasin A Receptor (EDAR))

Épitope: Middle Region

Reactivité: Humain, Souris, Rat, Chien, Boeuf (Vache), Cheval, Cobaye, Lapin

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp EDAR est non-conjugé

Application: Western Blotting (WB)

Séquence: PAPDKQGSPE LCLLSLVHLA REKSATSNKS AGIQSRRKKI LDVYANVCGV

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 92%, Rat: 100%

Attributs du produit: This is a rabbit polyclonal antibody against EDAR. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of human EDAR

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 448 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur EDAR

Antigène: EDAR (Ectodysplasin A Receptor (EDAR))

Autre désignation: EDAR (EDAR Produits)

Sujet: EDAR is a member of the tumor necrosis factor receptor family. It is a receptor for the soluble ligand ectodysplasin A, and can activate the nuclear factor-kappaB, JNK, and caspase-independent cell death pathways. It is required for the development of hair, teeth, and other ectodermal derivatives. Mutations in the gene encoding EDAR result in autosomal dominant and recessive forms of hypohidrotic ectodermal dysplasia.This gene encodes a member of the tumor necrosis factor receptor family. The encoded transmembrane protein is a receptor for the soluble ligand ectodysplasin A, and can activate the nuclear factor-kappaB, JNK, and caspase-independent cell death pathways. It is required for the development of hair, teeth, and other ectodermal derivatives. Mutations in this gene result in autosomal dominant and recessive forms of hypohidrotic ectodermal dysplasia. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: DL, ED1R, ED3, ED5, EDA-A1R, EDA1R, EDA3, HRM1
Protein Interaction Partner: Traf2, Traf1, Eda, FADD, TRADD, EDARADD, MAP3K14, TRAF3,
Protein Size: 448

Poids moléculaire: 48 kDa

ID gène: 10913

NCBI Accession: NM_022336, NP_071731

UniProt: Q9UNE0

Pathways: Tube Formation, Ubiquitin Proteasome Pathway