MRVI1 anticorps (N-Term)

N° du produit ABIN2773963

Détail du produit anti-MRVI1 anticorps

Antigène: MRVI1 (Murine Retrovirus Integration Site 1 Homolog (MRVI1))

Épitope: N-Term

Reactivité: Humain, Boeuf (Vache), Chien, Cobaye, Cheval, Souris, Lapin, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MRVI1 est non-conjugé

Application: Western Blotting (WB)

Séquence: LVNDQLPDIS ISEEDKKKNL ALLEEAKLVS ERFLTRRGRK SRSSPGDSPS

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%

Attributs du produit: This is a rabbit polyclonal antibody against MRVI1. It was validated on Western Blot.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the N-terminal region of Human MRVI1

Information d'application

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeat freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur MRVI1

Antigène: MRVI1 (Murine Retrovirus Integration Site 1 Homolog (MRVI1))

Autre désignation: MRVI1 (MRVI1 Produits)

Synonymes: anticorps BB115629, anticorps Irag, anticorps Ris1, anticorps IRAG, anticorps JAW1L, anticorps MRV integration site 1, anticorps murine retrovirus integration site 1 homolog, anticorps Mrvi1, anticorps MRVI1

Sujet: This gene is similar to a putative mouse tumor suppressor gene (Mrvi1) that is frequently disrupted by mouse AIDS-related virus (MRV). The encoded protein, which is found in the membrane of the endoplasmic reticulum, is similar to Jaw1, a lymphoid-restricted protein whose expression is down-regulated during lymphoid differentiation. This protein is a substrate of cGMP-dependent kinase-1 (PKG1) that can function as a regulator of IP3-induced calcium release. Studies in mouse suggest that MRV integration at Mrvi1 induces myeloid leukemia by altering the expression of a gene important for myeloid cell growth and/or differentiation, and thus this gene may function as a myeloid leukemia tumor suppressor gene. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene, and alternative translation start sites, including a non-AUG (CUG) start site, are used.
Protein Interaction Partner: MME, PRKG1, ITPR1,
Protein Size: 803

Poids moléculaire: 88 kDa

ID gène: 10335