OAS1 anticorps (Middle Region)

N° du produit ABIN2773987

Détail du produit anti-OAS1 anticorps

Antigène: OAS1 (2',5'-Oligoadenylate Synthetase 1, 40/46kDa (OAS1))

Épitope: Middle Region

Reactivité: Humain, Souris, Rat, Boeuf (Vache), Chien, Porc, Cheval, Lapin, Cobaye

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp OAS1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Séquence: RRQLTKPRPV ILDPADPTGN LGGGDPKGWR QLAQEAEAWL NYPCFKNWDG

Homologie: Cow: 93%, Dog: 93%, Guinea Pig: 87%, Horse: 93%, Human: 100%, Mouse: 93%, Pig: 93%, Rabbit: 86%, Rat: 93%

Attributs du produit: This is a rabbit polyclonal antibody against OAS1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of human OAS1

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 414 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-OAS1 (ABIN2773987)

Yu, Yan, Liu, Li, Liu, Zhu, Chen, Han: "Pattern recognition receptor-initiated innate antiviral response in mouse adipose cells." dans: Immunology and cell biology, Vol. 92, Issue 2, pp. 105-15, (2014) (PubMed).

Zhu, Chen, Yan, Liu, Li, Zhang, Yu, Chen, Han: "RIG-I-like receptors mediate innate antiviral response in mouse testis." dans: Molecular endocrinology (Baltimore, Md.), Vol. 27, Issue 9, pp. 1455-67, (2013) (PubMed).

Détails sur OAS1

Antigène: OAS1 (2',5'-Oligoadenylate Synthetase 1, 40/46kDa (OAS1))

Autre désignation: OAS1 (OAS1 Produits)

Synonymes: anticorps OAS1, anticorps IFI-4, anticorps OIAS, anticorps OIASI, anticorps L3, anticorps Pp2a2, anticorps 2',5'-oligoadenylate synthetase 1, anticorps 2'-5'-oligoadenylate synthetase 1, anticorps 2'-5' oligoadenylate synthetase 1A, anticorps protein phosphatase 2 catalytic subunit beta, anticorps OAS1, anticorps Oas1a, anticorps Ppp2cb, anticorps Oas1

Sujet: This protein is a member of the 2-5A synthetase family, essential proteins involved in the innate immune response to viral infection. The encoded protein is induced by interferons and uses adenosine triphosphate in 2'-specific nucleotidyl transfer reactions to synthesize 2',5'-oligoadenylates (2-5As). These molecules activate latent RNase L, which results in viral RNA degradation and the inhibition of viral replication.This gene encodes a member of the 2-5A synthetase family, essential proteins involved in the innate immune response to viral infection. The encoded protein is induced by interferons and uses adenosine triphosphate in 2'-specific nucleotidyl transfer reactions to synthesize 2',5'-oligoadenylates (2-5As). These molecules activate latent RNase L, which results in viral RNA degradation and the inhibition of viral replication. The three known members of this gene family are located in a cluster on chromosome 12. Mutations in this gene have been associated with host susceptibility to viral infection. Alternatively spliced transcript variants encoding different isoforms have been described.
Alias Symbols: IFI-4, OIAS, OIASI
Protein Interaction Partner: EXOC5, TRIM27, ACTN1, PRMT6, WBSCR22, RPL30, HCVgp1,
Protein Size: 414

Poids moléculaire: 47 kDa

ID gène: 4938

NCBI Accession: NM_001032409, NP_001027581

Pathways: Hepatitis C