THOC7 anticorps (C-Term)

N° du produit ABIN2774475

Détail du produit anti-THOC7 anticorps

Antigène: THOC7 (THO Complex 7 (THOC7))

Épitope: C-Term

Reactivité: Humain, Souris, Rat, Boeuf (Vache), Lapin, Chien, Cobaye, Cheval, Poisson zèbre (Danio rerio)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp THOC7 est non-conjugé

Application: Western Blotting (WB)

Séquence: ELEHLSHIKE SVEDKLELRR KQFHVLLSTI HELQQTLEND EKLSEVEEAQ

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 86%, Rabbit: 100%, Rat: 100%, Zebrafish: 90%

Attributs du produit: This is a rabbit polyclonal antibody against THOC7. It was validated on Western Blot.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the C-terminal region of Human THOC7

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 204 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur THOC7

Antigène: THOC7 (THO Complex 7 (THOC7))

Autre désignation: THOC7 (THOC7 Produits)

Synonymes: anticorps RGD1305475, anticorps NIF3L1BP1, anticorps fSAP24, anticorps 1500006O09Rik, anticorps 9230101K24Rik, anticorps Nif3l1bp1, anticorps THO complex 7, anticorps Thoc7, anticorps THOC7

Sujet: THOC7 is a component of the THO subcomplex of the TREX complex. The TREX complex specifically associates with spliced mRNA and not with unspliced pre-mRNA. It is recruited to spliced mRNAs by a transcription-independent mechanism. Binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export. The recruitment occurs via an interaction between ALYREF/THOC4 and the cap-binding protein NCBP1. DDX39B functions as a bridge between ALYREF/THOC4 and the THO complex. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. The recruitment of the TREX complex to the intronless viral mRNA occurs via an interaction between KSHV ORF57 protein and ALYREF/THOC4.
Alias Symbols: FLJ23445, NIF3L1BP1, fSAP24
Protein Interaction Partner: THOC2, RPA3, RPA2, RPA1, CKAP4, UBC, ZC3H15, TRMT112, PPIP5K2, THOC1, UBE3C, USP13, ZPR1, THOC5, VIM, S100A13, WDR36, ZCRB1, THOC3, ZNF606, THOC6, ALYREF, DDX39B, NIF3L1, CHD3, MED8, GOT2, MED18, MED22,
Protein Size: 204

Poids moléculaire: 22 kDa

ID gène: 80145

NCBI Accession: NM_025075, NP_079351

UniProt: Q6I9Y2