FBXO2 anticorps (C-Term)
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- Antigène Voir toutes FBXO2 Anticorps
- FBXO2 (F-Box Protein 2 (FBXO2))
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Épitope
- C-Term
- Reactivité
- Humain, Souris, Rat, Chien, Cheval, Boeuf (Vache), Cobaye, Poisson zèbre (Danio rerio), Lapin
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp FBXO2 est non-conjugé
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Application
- Western Blotting (WB)
- Séquence
- LAEFATGQVA VPEDGSWMEI SHTFIDYGPG VRFVRFEHGG QDSVYWKGWF
- Homologie
- Cow: 92%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 85%, Rat: 93%, Zebrafish: 77%
- Attributs du produit
- This is a rabbit polyclonal antibody against Fbxo2. It was validated on Western Blot.
- Purification
- Affinity Purified
- Top Product
- Discover our top product FBXO2 Anticorps primaire
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- Indications d'application
- Optimal working dilutions should be determined experimentally by the investigator.
- Commentaires
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Antigen size: 297 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freeze-thaw cycles.
- Stock
- -20 °C
- Stockage commentaire
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Antigène
- FBXO2 (F-Box Protein 2 (FBXO2))
- Autre désignation
- Fbxo2 (FBXO2 Produits)
- Synonymes
- anticorps FBG1, anticorps FBX2, anticorps Fbs1, anticorps NFB42, anticorps OCP1, anticorps Fbs2, anticorps Prpl4, anticorps F-box protein 2, anticorps FBXO2, anticorps Fbxo2
- Sujet
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Fbxo2 is a substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Involved in the endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins by recognizing and binding sugar chains on unfolded glycoproteins that are retrotranslocated into the cytosol and promoting their ubiquitination and subsequent degradation. Prevents formation of cytosolic aggregates of unfolded glycoproteins that have been retrotranslocated into the cytosol. Able to recognize and bind denatured glycoproteins, preferentially those of the high-mannose type.
Alias Symbols: FBG1, FBX2, Fbs1, Fbs2, MGC54895, NFB42, Prpl4
Protein Interaction Partner: Stat1, Cul1, Skp1a, Bace1, Vcp,
Protein Size: 297 - Poids moléculaire
- 34 kDa
- ID gène
- 230904
- NCBI Accession
- NM_176848, NP_789818
- UniProt
- Q80UW2
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