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CHFR anticorps (N-Term)

CHFR Reactivité: Humain, Souris, Rat, Lapin, Poisson zèbre (Danio rerio), Boeuf (Vache), Chien, Cheval, Cobaye WB, IHC Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN2774757
  • Antigène Voir toutes CHFR Anticorps
    CHFR (Checkpoint with Forkhead and Ring Finger Domains (CHFR))
    Épitope
    • 8
    • 6
    • 6
    • 6
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reactivité
    Humain, Souris, Rat, Lapin, Poisson zèbre (Danio rerio), Boeuf (Vache), Chien, Cheval, Cobaye
    Hôte
    • 41
    • 3
    • 1
    Lapin
    Clonalité
    • 42
    • 3
    Polyclonal
    Conjugué
    • 18
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    Cet anticorp CHFR est non-conjugé
    Application
    • 26
    • 25
    • 6
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC)
    Séquence
    REWTIGRRRG CDLSFPSNKL VSGDHCRIVV DEKSGQVTLE DTSTSGTVIN
    Homologie
    Cow: 93%, Dog: 93%, Guinea Pig: 100%, Horse: 93%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 86%
    Attributs du produit
    This is a rabbit polyclonal antibody against CHFR. It was validated on Western Blot using a cell lysate as a positive control.
    Purification
    Affinity Purified
    Immunogène
    The immunogen is a synthetic peptide directed towards the N terminal region of human CHFR
    Top Product
    Discover our top product CHFR Anticorps primaire
  • Indications d'application
    Optimal working dilutions should be determined experimentally by the investigator.
    Commentaires

    Antigen size: 623 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Avoid repeated freeze-thaw cycles.
    Stock
    -20 °C
    Stockage commentaire
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Antigène
    CHFR (Checkpoint with Forkhead and Ring Finger Domains (CHFR))
    Autre désignation
    CHFR (CHFR Produits)
    Synonymes
    anticorps RNF116, anticorps RNF196, anticorps CHFR, anticorps fc43f10, anticorps si:dkey-69h6.7, anticorps wu:fc43f10, anticorps rnf116, anticorps rnf196, anticorps 5730484M20Rik, anticorps C230082M18, anticorps checkpoint with forkhead and ring finger domains, anticorps checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase, anticorps checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase L homeolog, anticorps CHFR, anticorps chfr, anticorps Chfr, anticorps chfr.L
    Sujet
    CHFR is an E3 ubiquitin-protein ligase required to transiently arrest cells in early prophase when they are exposed to microtubule poisons. It acts in early prophase before chromosome condensation, when the centrosome moves apart from each other along the periphery of the nucleus. CHFR probably promotes the formation of 'Lys-63'-linked polyubiquitin chains and functions with the specific ubiquitin-conjugating UBC13-MMS2 (UBE2N-UBE2V2) heterodimer. Substrates that are polyubiquitinated at 'Lys-63' are usually not targeted for degradation, but are rather involved in signaling cellular stress. This suggests that it may be involved in signaling the presence of mitotic stress caused by microtubule poisons.
    Alias Symbols: FLJ10796, FLJ33629, RNF116, RNF196
    Protein Interaction Partner: USP7, VIM, UBE2D2, AURKA, HLTF, RANBP2, PLK1, PCNA, MCM2, HDAC2, HDAC1, CDK5, CDC20, PARP1, SIN3A, CHFR, UBC13, SUMO1, UBE2I, LRP1, UBE2V1, UBE2N, UBE2D1, TRIM9, RNF125, CBLC, RNF7, RELA, RNF8, HIST2H2BE, HIST2H2AC, UBC, SMARCD1, SMARCB1, SMARCA4, KIF22,
    Protein Size: 623
    Poids moléculaire
    69 kDa
    ID gène
    55743
    NCBI Accession
    NM_018223, NP_060693
    UniProt
    Q96EP1
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