RAD18 anticorps (Middle Region)
-
- Antigène Voir toutes RAD18 Anticorps
- RAD18 (E3 ubiquitin-protein ligase RAD18 (RAD18))
-
Épitope
- Middle Region
-
Reactivité
- Humain, Rat, Souris, Porc, Lapin, Boeuf (Vache), Chien, Cheval, Cobaye
-
Hôte
- Lapin
-
Clonalité
- Polyclonal
-
Conjugué
- Cet anticorp RAD18 est non-conjugé
-
Application
- Western Blotting (WB)
- Séquence
- KQVTKVDCPV CGVNIPESHI NKHLDSCLSR EEKKESLRSS VHKRKPLPKT
- Homologie
- Cow: 100%, Dog: 86%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%
- Attributs du produit
- This is a rabbit polyclonal antibody against RAD18. It was validated on Western Blot using a cell lysate as a positive control.
- Purification
- Affinity Purified
- Immunogène
- The immunogen is a synthetic peptide directed towards the middle region of human RAD18
- Top Product
- Discover our top product RAD18 Anticorps primaire
-
-
- Indications d'application
- Optimal working dilutions should be determined experimentally by the investigator.
- Commentaires
-
Antigen size: 495 AA
- Restrictions
- For Research Use only
-
- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freeze-thaw cycles.
- Stock
- -20 °C
- Stockage commentaire
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
-
-
Recognition of forked and single-stranded DNA structures by human RAD18 complexed with RAD6B protein triggers its recruitment to stalled replication forks." dans: Genes to cells : devoted to molecular & cellular mechanisms, Vol. 13, Issue 4, pp. 343-54, (2008) (PubMed).
: "
-
Recognition of forked and single-stranded DNA structures by human RAD18 complexed with RAD6B protein triggers its recruitment to stalled replication forks." dans: Genes to cells : devoted to molecular & cellular mechanisms, Vol. 13, Issue 4, pp. 343-54, (2008) (PubMed).
-
- Antigène
- RAD18 (E3 ubiquitin-protein ligase RAD18 (RAD18))
- Autre désignation
- RAD18 (RAD18 Produits)
- Synonymes
- anticorps RNF73, anticorps 2810024C04Rik, anticorps Rad18sc, anticorps zgc:55577, anticorps RAD18, anticorps DDBDRAFT_0218120, anticorps DDBDRAFT_0304878, anticorps DDB_0218120, anticorps DDB_0304878, anticorps DKFZp469H0810, anticorps RAD18, E3 ubiquitin protein ligase, anticorps RAD18 E3 ubiquitin protein ligase, anticorps E3 ubiquitin-protein ligase RAD18, anticorps E3 ubiquitin-protein ligase, anticorps DNA repair protein and ATPase, anticorps C3HC4-type zinc finger-containing protein, anticorps RAD18, anticorps Rad18, anticorps rad18
- Sujet
-
RAD18 is highly similar to S. cerevisiae DNA damage repair protein Rad18. Yeast Rad18 functions through its interaction with Rad6, which is an ubiquitin-conjugating enzyme required for post-replication repair of damaged DNA. Similar to its yeast counterpart, RAD18 is able to interact with the human homolog of yeast Rad6 protein through a conserved ring-finger motif. Mutation of this motif results in defective replication of UV-damaged DNA and hypersensitivity to multiple mutagens. The protein encoded by this gene is highly similar to S. cerevisiae DNA damage repair protein Rad18. Yeast Rad18 functions through its interaction with Rad6, which is an ubiquitin-conjugating enzyme required for post-replication repair of damaged DNA. Similar to its yeast counterpart, this protein is able to interact with the human homolog of yeast Rad6 protein through a conserved ring-finger motif. Mutation of this motif results in defective replication of UV-damaged DNA and hypersensitivity to multiple mutagens. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: RNF73
Protein Interaction Partner: TAX1BP1, UBC, SHPRH, RAD18, SIVA1, USP2, UBE2B, UBE2A, HLTF, PCNA, BPLF1, USP5, DBF4, BRCA1, DZIP3, POLH, DTL, Ankrd32, MLKL, ECT2, RPL10A, TRIM23, PCGF6, TRIM8, RFC2, CPD, SPRTN, ZMYM2, MAPK8, POLN, WRNIP1, gag-pol, ORC2, SUMO2, POLK, NBN, Smc6, HIST1H2A
Protein Size: 495 - Poids moléculaire
- 56 kDa
- ID gène
- 56852
- NCBI Accession
- NM_020165, NP_064550
- UniProt
- Q9NS91
-