ADRB1 anticorps (Middle Region)

N° du produit ABIN2774823

Détail du produit anti-ADRB1 anticorps

Antigène: ADRB1 (Adrenergic, beta-1-, Receptor (ADRB1))

Épitope: Middle Region

Reactivité: Humain, Souris, Rat, Chien, Porc, Lapin, Cobaye

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ADRB1 est non-conjugé

Application: Western Blotting (WB)

Séquence: CTVWAISALV SFLPILMHWW RAESDEARRC YNDPKCCDFV TNRAYAIASS

Homologie: Dog: 87%, Guinea Pig: 93%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 93%, Rat: 100%

Attributs du produit: This is a rabbit polyclonal antibody against ADRB1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of human ADRB1

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 477 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-ADRB1 (ABIN2774823)

Wei, Shen, Song, Qiu, Luo: "Propranolol sensitizes thyroid cancer cells to cytotoxic effect of vemurafenib." dans: Oncology reports, Vol. 36, Issue 3, pp. 1576-84, (2016) (PubMed).

Tsai, Lee, Chen, Kao, Lu, Lin, Chen, Chen: "Testosterone replacement increases aged pulmonary vein and left atrium arrhythmogenesis with enhanced adrenergic activity." dans: International journal of cardiology, Vol. 176, Issue 1, pp. 110-8, (2014) (PubMed).

Détails sur ADRB1

Antigène: ADRB1 (Adrenergic, beta-1-, Receptor (ADRB1))

Autre désignation: ADRB1 (ADRB1 Produits)

Sujet: The adrenergic receptors (subtypes alpha 1, alpha 2, beta 1, and beta 2) are a prototypic family of guanine nucleotide binding regulatory protein-coupled receptors that mediate the physiological effects of the hormone epinephrine and the neurotransmitter norepinephrine. Specific polymorphisms in ADRB1 gene have been shown to affect the resting heart rate and can be involved in heart failure.The adrenergic receptors (subtypes alpha 1, alpha 2, beta 1, and beta 2) are a prototypic family of guanine nucleotide binding regulatory protein-coupled receptors that mediate the physiological effects of the hormone epinephrine and the neurotransmitter norepinephrine. Specific polymorphisms in this gene have been shown to affect the resting heart rate and can be involved in heart failure. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: ADRB1R, B1AR, BETA1AR, RHR
Protein Interaction Partner: GPRASP1, GPRASP2, SNTA1, ARRB2, ARRB1, MAGI2, DLG4, GRB2, ADRA2A, MAGI3, DLGAP2, GOPC, GIPC1, SH3GL2, SH3GL3, DLG1, NOS1,
Protein Size: 477

Poids moléculaire: 51 kDa

ID gène: 153

NCBI Accession: NM_000684, NP_000675

UniProt: P08588

Pathways: cAMP Metabolic Process, Cellular Glucan Metabolic Process, Regulation of Muscle Cell Differentiation, Synaptic Membrane, Regulation of G-Protein Coupled Receptor Protein Signaling, G-protein mediated Events, Interaction of EGFR with phospholipase C-gamma, Brown Fat Cell Differentiation