Annexin VII anticorps (N-Term)

N° du produit ABIN2774843

Détail du produit anti-Annexin VII anticorps

Antigène: Annexin VII (ANXA7) (Annexin A7 (ANXA7))

Épitope: N-Term

Reactivité: Humain, Souris, Rat, Boeuf (Vache), Lapin, Chien, Cobaye, Cheval

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Annexin VII est non-conjugé

Application: Western Blotting (WB)

Séquence: MSYPGYPPTG YPPFPGYPPA GQESSFPPSG QYPYPSGFPP MGGGAYPQVP

Homologie: Cow: 86%, Dog: 93%, Guinea Pig: 93%, Horse: 93%, Human: 100%, Mouse: 86%, Rabbit: 93%, Rat: 100%

Attributs du produit: This is a rabbit polyclonal antibody against ANXA7. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Protein A purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human ANXA7

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 466 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-Annexin VII (ABIN2774843)

Satoh, Nakano, Shibata, Maki: "The penta-EF-hand domain of ALG-2 interacts with amino-terminal domains of both annexin VII and annexin XI in a Ca2+-dependent manner." dans: Biochimica et biophysica acta, Vol. 1600, Issue 1-2, pp. 61-7, (2002) (PubMed).

Détails sur Annexin VII

Antigène: Annexin VII (ANXA7) (Annexin A7 (ANXA7))

Autre désignation: ANXA7 (ANXA7 Produits)

Synonymes: anticorps ANX7, anticorps SNX, anticorps SYNEXIN, anticorps AI265384, anticorps AI316497, anticorps Anx7, anticorps synexin, anticorps anxa7, anticorps MGC76267, anticorps MGC82023, anticorps ANXA7, anticorps MGC83033, anticorps annexin A7, anticorps annexin VII, anticorps annexin A7 S homeolog, anticorps ANXA7, anticorps Anxa7, anticorps anxa7, anticorps anxa7.S, anticorps PTRG_02166, anticorps BRAFLDRAFT_231082, anticorps PAAG_00136, anticorps MCYG_04180, anticorps VDBG_06328, anticorps MGYG_02426

Sujet: ANXA7 is a member of the annexin family of calcium-dependent phospholipid binding proteins. The Annexin VII gene contains 14 exons and spans approximately 34 kb of DNA. An alternatively spliced cassette exon results in two mRNA transcripts of 2.0 and 2.4 kb which are predicted to generate two protein isoforms differing in their N-terminal domain. The alternative splicing event is tissue specific and the mRNA containing the cassette exon is prevalent in brain, heart and skeletal muscle. The transcripts also differ in their 3'-non coding regions by the use of two alternative poly(A) signals. The selection of poly(A) signals is independent of the mRNA splicing pattern. Annexin VII encodes a protein with a molecular weight of approximately 51 kDa with a unique, highly hydrophobic N-terminal domain of 167 amino acids and a conserved C-terminal region of 299 amino acids. The latter domain is composed of alternating hydrophobic and hydrophilic segments. Structural analysis of the protein suggests that Annexin VII is a membrane binding protein with diverse properties including voltage-sensitive calcium channel activity, ion selectivity and membrane fusion.
Alias Symbols: SNX, ANX7, SYNEXIN
Protein Interaction Partner: UBC, PAX8, ATP4A, SRC, Prkcb, Prkcg, Prkca, PRKG1, PRKACA, VCP, ANXA4, CUL4B, CUL5, ALG2, ELAVL1, CCDC90B, WDR18, LRIF1, OTUB1, CPSF3L, SEMA5B, INPP5K, ACTL6B, CSAD, SDF4, MED31, TAF5L, TRMT2A, TUBB2B, CPNE2, ZNF431, KLHL23, DOCK7, WDR73, FBN3, RBM48, ADA
Protein Size: 466

Poids moléculaire: 51 kDa

ID gène: 310

NCBI Accession: NM_001156, NP_001147

UniProt: Q5T0M6