MCM2 anticorps (N-Term)
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- Antigène Voir toutes MCM2 Anticorps
- MCM2 (Minichromosome Maintenance Complex Component 2 (MCM2))
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Épitope
- N-Term
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Reactivité
- Humain, Souris, Rat, Chien, Cheval, Lapin, Boeuf (Vache), Cobaye, Porc
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp MCM2 est non-conjugé
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Application
- Western Blotting (WB)
- Séquence
- PGRSSRRTDA LTSSPGRDLP PFEDESEGLL GTEGPLEEEE DGEELIGDGM
- Homologie
- Cow: 100%, Dog: 93%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 93%, Pig: 100%, Rabbit: 100%, Rat: 93%
- Attributs du produit
- This is a rabbit polyclonal antibody against MCM2. It was validated on Western Blot using a cell lysate as a positive control.
- Purification
- Protein A purified
- Immunogène
- The immunogen is a synthetic peptide directed towards the N terminal region of human MCM2
- Top Product
- Discover our top product MCM2 Anticorps primaire
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- Indications d'application
- Optimal working dilutions should be determined experimentally by the investigator.
- Commentaires
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Antigen size: 904 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freeze-thaw cycles.
- Stock
- -20 °C
- Stockage commentaire
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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Prohibitin physically interacts with MCM proteins and inhibits mammalian DNA replication." dans: Cell cycle (Georgetown, Tex.), Vol. 8, Issue 10, pp. 1621-9, (2009) (PubMed).
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Prohibitin physically interacts with MCM proteins and inhibits mammalian DNA replication." dans: Cell cycle (Georgetown, Tex.), Vol. 8, Issue 10, pp. 1621-9, (2009) (PubMed).
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- Antigène
- MCM2 (Minichromosome Maintenance Complex Component 2 (MCM2))
- Autre désignation
- MCM2 (MCM2 Produits)
- Synonymes
- anticorps CG7538, anticorps DmMCM2, anticorps DmMcm2, anticorps DmeMCM2, anticorps Dmel\\CG7538, anticorps MCM2, anticorps MCM2-7, anticorps MCM2_DROME, anticorps McM2, anticorps PCR3, anticorps dMCM2, anticorps l(3)rL074, anticorps XMcm2, anticorps bm28, anticorps ccnl1, anticorps cdc19, anticorps cdcl1, anticorps mitotin, anticorps cb737, anticorps chunp6905, anticorps BM28, anticorps CCNL1, anticorps CDCL1, anticorps D3S3194, anticorps MITOTIN, anticorps MCM7, anticorps AA959861, anticorps AW476101, anticorps Mcmd2, anticorps mKIAA0030, anticorps Minichromosome maintenance 2, anticorps minichromosome maintenance complex component 2, anticorps minichromosome maintenance complex component 2 L homeolog, anticorps Mcm2, anticorps mcm2, anticorps MCM2, anticorps mcm2.L
- Sujet
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The protein encoded by MCM2 is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein forms a complex with MCM4, 6, and 7, and has been shown to regulate the helicase activity of the complex. This protein is phosphorylated, and thus regulated by, protein kinases CDC2 and CDC7.
Alias Symbols: BM28, CCNL1, CDCL1, cdc19, D3S3194, MITOTIN
Protein Interaction Partner: HUWE1, MCM6, CHFR, SUMO2, MCMBP, UBC, SUMO1, MDM2, MCM7, MCM4, HSP90AB1, ACLY, PRRC1, HYOU1, CAP1, NCL, POLA1, TONSL, SNF8, ELL, TCEA1, POLR2A, CDK6, CDK4, CDC6, MCM10, ORC6, CCNB2, VCAM1, P2RX4, ORC5, ORC2, MCM5, MCM3, ITGA4, FN1, CSNK2A1, CDKN2A, DBF4,
Protein Size: 904 - Poids moléculaire
- 99 kDa
- ID gène
- 4171
- NCBI Accession
- NM_004526, NP_004517
- UniProt
- P49736
- Pathways
- Réparation de l'ADN, Mitotic G1-G1/S Phases, DNA Replication, Chromatin Binding, Synthesis of DNA
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