MCM4 anticorps (N-Term)
-
- Antigène Voir toutes MCM4 Anticorps
- MCM4 (Minichromosome Maintenance Deficient 4 (MCM4))
-
Épitope
- N-Term
-
Reactivité
- Humain, Souris, Rat, Lapin, Boeuf (Vache), Cobaye, Chien, Cheval
-
Hôte
- Lapin
-
Clonalité
- Polyclonal
-
Conjugué
- Cet anticorp MCM4 est non-conjugé
-
Application
- Western Blotting (WB)
- Séquence
- SRVEGTPRSG VRGTPVRQRP DLGSAQKGLQ VDLQSDGAAA EDIVASEQSL
- Homologie
- Cow: 86%, Dog: 92%, Guinea Pig: 93%, Horse: 93%, Human: 100%, Mouse: 93%, Rabbit: 93%, Rat: 93%
- Attributs du produit
- This is a rabbit polyclonal antibody against MCM4. It was validated on Western Blot using a cell lysate as a positive control.
- Purification
- Protein A purified
- Immunogène
- The immunogen is a synthetic peptide directed towards the N terminal region of human MCM4
- Top Product
- Discover our top product MCM4 Anticorps primaire
-
-
- Indications d'application
- Optimal working dilutions should be determined experimentally by the investigator.
- Commentaires
-
Antigen size: 863 AA
- Restrictions
- For Research Use only
-
- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freeze-thaw cycles.
- Stock
- -20 °C
- Stockage commentaire
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
-
- Antigène
- MCM4 (Minichromosome Maintenance Deficient 4 (MCM4))
- Autre désignation
- MCM4 (MCM4 Produits)
- Synonymes
- anticorps cdc21, anticorps CDC21, anticorps CDC54, anticorps NKCD, anticorps NKGCD, anticorps P1-CDC21, anticorps hCdc21, anticorps 19G, anticorps AI325074, anticorps AU045576, anticorps Cdc21, anticorps Mcmd4, anticorps mKIAA4003, anticorps mcdc21, anticorps cb1025, anticorps fc12c09, anticorps fj85g09, anticorps hm:zeh1616, anticorps wu:fc12c09, anticorps wu:fj85g09, anticorps zeh1616, anticorps minichromosome maintenance complex component 4 L homeolog, anticorps minichromosome maintenance complex component 4 S homeolog, anticorps minichromosome maintenance complex component 4, anticorps mcm4.L, anticorps mcm4.S, anticorps MCM4, anticorps mcm4, anticorps Mcm4
- Sujet
-
The protein encoded by MCM4 is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 6 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of this protein by CDC2 kinase reduces the DNA helicase activity and chromatin binding of the MCM complex. This gene is mapped to a region on the chromosome 8 head-to-head next to the PRKDC/DNA-PK, a DNA-activated protein kinase involved in the repair of DNA double-strand breaks. Alternatively spliced transcript variants encoding the same protein have been reported.
Alias Symbols: CDC21, CDC54, hCdc21, P1-CDC21
Protein Interaction Partner: HUWE1, UBC, PCNA, SUMO2, FKBP5, MCMBP, MDM2, POLK, CLUH, NCKAP1, CAP1, CAP2, EIF3B, MCM2, KPNA3, PRMT1, FKBP4, MCM7, MCM6, FBXW4, FBXO46, ITGA4, CDC5L, gag-pol, ORC6, CCNA1, VCAM1, DBF4, CDC7, LIG4, MCM5, MCM3, DCTN2, SF3A1, UBD, NEDD8, TONSL, SIRT7, ASF1
Protein Size: 863 - Poids moléculaire
- 95 kDa
- ID gène
- 4173
- NCBI Accession
- NM_182746, NP_877423
- UniProt
- P33991
- Pathways
- Réparation de l'ADN, Mitotic G1-G1/S Phases, DNA Replication, Chromatin Binding, Synthesis of DNA
-