BAT1 anticorps (C-Term)

N° du produit ABIN2775195

Détail du produit anti-BAT1 anticorps

Antigène: BAT1 (DDX39) (DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 39 (DDX39))

Épitope: C-Term

Reactivité: Humain, Rat, Chien, Souris, Boeuf (Vache), Chévre, Cobaye, Cheval, Lapin, Poisson zèbre (Danio rerio)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp BAT1 est non-conjugé

Application: Western Blotting (WB)

Séquence: YDMPEDSDTY LHRVARAGRF GTKGLAITFV SDENDAKILN DVQDRFEVNI

Homologie: Cow: 100%, Dog: 100%, Goat: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 93%

Attributs du produit: This is a rabbit polyclonal antibody against BAT1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the C terminal region of human BAT1

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 428 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-BAT1 (ABIN2775195)

Bouley, Pionneau, Varinot, Biard, Genestie, Antoine, Coulet, Stern, Stoppa-Lyonnet, Soubrier: "Proteomic analysis of BRCA1-depleted cell line reveals a putative role for replication protein A2 up-regulation in BRCA1 breast tumor development." dans: Proteomics. Clinical applications, Vol. 4, Issue 5, pp. 489-98, (2010) (PubMed).

Détails sur BAT1

Antigène: BAT1 (DDX39) (DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 39 (DDX39))

Autre désignation: BAT1 (DDX39 Produits)

Sujet: BAT1 is a member of the DEAD protein family of ATP-dependent RNA helicases. Members of this family are involved in a number of cellular functions including initiation of translation, RNA splicing, and ribosome assembly. A cluster of genes, BAT1-BAT5, has been localized in the vicinity of the genes for TNF alpha and TNF beta. These genes are all within the human major histocompatibility complex class III region. This protein is a negative regulator of inflammation. It is also thought to be a translation initiation factor. This gene is a strong candidate gene for rheumatoid arthritis. There are multiple alternatively spliced transcript variants known for this gene but only two have been fully described. Both of these variants encode the same isoform. This gene has been found to have multiple polyadenylation sites.
Alias Symbols: BAT1, UAP56, D6S81E
Protein Interaction Partner: THOC3, THOC2, ALYREF, NCBP1, STAU1, SHFM1, UBC, MDM2, WWOX, SUZ12, EED, RNF2, BMI1, RBBP4, C12orf10, NDRG1, HSPD1, GSR, SRPK2, UBD, VCAM1, ITGA4, IL7R, FN1, ATF2, BARD1, WIBG, MAGOHB, WDR74, VPS33B, LSM4, THOC1, RBM8A, DHX38, TXNL1, UBE3A, RPS7, EIF4A2, R
Protein Size: 428

Poids moléculaire: 47 kDa

ID gène: 7919

NCBI Accession: NM_080598, NP_542165

UniProt: Q13838

Pathways: Ribonucleoprotein Complex Subunit Organization