BTRC anticorps (C-Term)
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- Antigène Voir toutes BTRC Anticorps
- BTRC (beta-Transducin Repeat Containing (BTRC))
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Épitope
- C-Term
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Reactivité
- Humain, Souris, Rat, Lapin, Boeuf (Vache), Chien, Cobaye, Cheval
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp BTRC est non-conjugé
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Application
- Western Blotting (WB)
- Séquence
- LVEHSGRVFR LQFDEFQIVS SSHDDTILIW DFLNDPAAHA EPPRSPSRTY
- Homologie
- Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 93%, Human: 100%, Mouse: 93%, Rabbit: 100%, Rat: 86%
- Attributs du produit
- This is a rabbit polyclonal antibody against Btrc. It was validated on Western Blot.
- Purification
- Affinity Purified
- Top Product
- Discover our top product BTRC Anticorps primaire
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- Indications d'application
- Optimal working dilutions should be determined experimentally by the investigator.
- Commentaires
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Antigen size: 605 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freeze-thaw cycles.
- Stock
- -20 °C
- Stockage commentaire
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Antigène
- BTRC (beta-Transducin Repeat Containing (BTRC))
- Autre désignation
- Btrc (BTRC Produits)
- Synonymes
- anticorps BTRC, anticorps Beta-TrCP, anticorps betaTrCP, anticorps btrcp, anticorps btrcp1, anticorps fbw1a, anticorps fbxw1, anticorps fbxw1a, anticorps fwd1, anticorps btrc, anticorps beta-TrCP, anticorps BETA-TRCP, anticorps FBW1A, anticorps FBXW1, anticorps FBXW1A, anticorps FWD1, anticorps bTrCP, anticorps bTrCP1, anticorps beta-TrCP1, anticorps btrc-a, anticorps Beta-Trcp1, anticorps Fbw1a, anticorps HOS, anticorps Slimb, anticorps b-TrCP, anticorps mKIAA4123, anticorps beta-transducin repeat containing E3 ubiquitin protein ligase, anticorps beta-transducin repeat containing, anticorps beta-TrCP, anticorps beta-transducin repeat containing E3 ubiquitin protein ligase S homeolog, anticorps beta-transducin repeat containing protein, anticorps BTRC, anticorps btrc, anticorps LOC100634006, anticorps Btrc, anticorps btrc.S
- Sujet
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Btrc is a substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It recognizes and binds to phosphorylated target proteins. SCF(BTRC) mediates the ubiquitination of CTNNB1 and participates in Wnt signaling. SCF(BTRC) mediates the ubiquitination of NFKBIA, NFKBIB and NFKBIE, the degradation frees the associated NFKB1 to translocate into the nucleus and to activate transcription. Ubiquitination of NFKBIA occurs at 'Lys-21' and 'Lys-22'. SCF(BTRC) mediates the ubiquitination of phosphorylated NFKB1/nuclear factor NF-kappa-B p105 subunit, ATF4, SMAD3, SMAD4, CDC25A, DLG1, FBXO5 and probably NFKB2. SCF(BTRC) mediates the ubiquitination of phosphorylated SNAI1.
Alias Symbols: Beta-Trcp1, FWD1, Fbw1a, KIAA4123, Slimb, b-TrCP, beta-TrCP, mKIAA4123, HOS
Protein Interaction Partner: ZRANB1, Tpx2, Taz, Per2, Cul1, Skp1a, Reg1, Stat1, Nfe2l2, Per1, Htt, Cops2, Ikbkb, Nkx3-2, Cdc25b, Nfkbia, Gli2,
Protein Size: 605 - Poids moléculaire
- 69 kDa
- ID gène
- 12234
- NCBI Accession
- NM_001037758, NP_001032847
- UniProt
- Q3ULA2
- Pathways
- Cycle Cellulaire, Signalisation Hedgehog
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