BAG2 anticorps (C-Term)

N° du produit ABIN2775278

Détail du produit anti-BAG2 anticorps

Antigène: BAG2 (BCL2-Associated Athanogene 2 (BAG2))

Épitope: C-Term

Reactivité: Humain, Rat, Souris, Chien, Lapin, Poisson zèbre (Danio rerio), Boeuf (Vache), Cobaye, Cheval

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp BAG2 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Séquence: VDQKFQSIVI GCALEDQKKI KRRLETLLRN IENSDKAIKL LEHSKGAGSK

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 100%

Attributs du produit: This is a rabbit polyclonal antibody against BAG2. It was validated on Western Blot and immunohistochemistry.

Purification: Protein A purified

Immunogène: The immunogen is a synthetic peptide directed towards the C terminal region of human BAG2

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 211 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-BAG2 (ABIN2775278)

Yue, Zhao, Liu, Zhang, Yu, Wang, Zheng, Liu, Li, Feng, Hu: "BAG2 promotes tumorigenesis through enhancing mutant p53 protein levels and function." dans: eLife, Vol. 4, (2015) (PubMed).

Détails sur BAG2

Antigène: BAG2 (BCL2-Associated Athanogene 2 (BAG2))

Autre désignation: BAG2 (BAG2 Produits)

Synonymes: anticorps bag2, anticorps MGC89300, anticorps BAG2, anticorps ATBAG2, anticorps BCL-2-associated athanogene 2, anticorps MTG10.13, anticorps MTG10_13, anticorps BAG-2, anticorps dJ417I1.2, anticorps zgc:64195, anticorps 2610042A13Rik, anticorps BC016230, anticorps BCL2 associated athanogene 2, anticorps BCL-2-associated athanogene 2, anticorps BCL2-associated athanogene 2, anticorps Bcl2-associated athanogene 2, anticorps bag2, anticorps BAG2, anticorps Bag2

Sujet: BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The predicted BAG2 protein contains 211 amino acids. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner.BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The predicted BAG2 protein contains 211 amino acids. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner.
Alias Symbols: RP3-496N17.2, BAG-2, KIAA0576, MGC149462, dJ417I1.2
Protein Interaction Partner: BAG2, UBC, TP53, LGALS3BP, TUBGCP2, TUBG1, STIP1, TAB1, STUB1, DNAJB6, MLF2, TTC1, STXBP2, SGTA, DNAJB1, HSPA8, SHFM1, PINK1, RPA3, RPA2, RPA1, AHNAK, PARK2, LATS2, TARDBP, EGFR, BAG3, HDAC11, SOX2, NPM1, PAN2, WDR83, WDR77, CCAR2, METTL21B, DNAJC6, NOS2,
Protein Size: 211

Poids moléculaire: 23 kDa

ID gène: 9532

NCBI Accession: NM_004282, NP_004273

UniProt: O95816