Perforin 1 anticorps (N-Term)
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- Antigène Voir toutes Perforin 1 (PRF1) Anticorps
- Perforin 1 (PRF1) (Perforin 1 (Pore Forming Protein) (PRF1))
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Épitope
- N-Term
- Reactivité
- Humain, Rat, Boeuf (Vache), Porc, Cheval, Chien, Cobaye, Lapin
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp Perforin 1 est non-conjugé
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Application
- Western Blotting (WB)
- Séquence
- SVAGSHSQAA NFAAQKTHQD QYSFSTDTVE CRFYSFHVVH TPPLHPDFKR
- Homologie
- Cow: 77%, Dog: 92%, Guinea Pig: 77%, Horse: 85%, Human: 100%, Pig: 100%, Rabbit: 92%, Rat: 77%
- Attributs du produit
- This is a rabbit polyclonal antibody against PRF1. It was validated on Western Blot using a cell lysate as a positive control.
- Purification
- Affinity Purified
- Immunogène
- The immunogen is a synthetic peptide directed towards the N terminal region of human PRF1
- Top Product
- Discover our top product PRF1 Anticorps primaire
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- Indications d'application
- Optimal working dilutions should be determined experimentally by the investigator.
- Commentaires
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Antigen size: 555 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freeze-thaw cycles.
- Stock
- -20 °C
- Stockage commentaire
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Antigène
- Perforin 1 (PRF1) (Perforin 1 (Pore Forming Protein) (PRF1))
- Autre désignation
- PRF1 (PRF1 Produits)
- Synonymes
- anticorps FLH2, anticorps HPLH2, anticorps P1, anticorps PFN1, anticorps PFP, anticorps PRF1, anticorps Pfn, anticorps Pfp, anticorps Prf-1, anticorps Cyta, anticorps RATCYTA, anticorps LOC443187, anticorps perforin, anticorps prf1, anticorps cytolysin, anticorps perforin-1, anticorps perforin-1-like, anticorps perforin 1, anticorps perforin 1 (pore forming protein), anticorps perforin, anticorps perforin 1 L homeolog, anticorps PRF1, anticorps Prf1, anticorps LOC443187, anticorps prf1, anticorps prf1.L
- Sujet
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PRF1 has structural and functional similarities to complement component 9 (C9). Like C9, this protein creates transmembrane tubules and is capable of lysing non-specifically a variety of target cells. This protein is one of the main cytolytic proteins of cytolytic granules, and it is known to be a key effector molecule for T-cell- and natural killer-cell-mediated cytolysis. Defects in the gene encoding PRF1 cause familial hemophagocytic lymphohistiocytosis type 2 (HPLH2), a rare and lethal autosomal recessive disorder of early childhood. The protein encoded by this gene has structural and functional similarities to complement component 9 (C9). Like C9, this protein creates transmembrane tubules and is capable of lysing non-specifically a variety of target cells. This protein is one of the main cytolytic proteins of cytolytic granules, and it is known to be a key effector molecule for T-cell- and natural killer-cell-mediated cytolysis. Defects in this gene cause familial hemophagocytic lymphohistiocytosis type 2 (HPLH2), a rare and lethal autosomal recessive disorder of early childhood. Alternative splicing results in multiple transcript variants encoding the same protein.
Alias Symbols: FLH2, HPLH2, MGC65093, P1, PFP, PFN1
Protein Interaction Partner: KRT31, FBXO6, PRF1, TRIM54, DDX24, GZMB, CALR,
Protein Size: 555 - Poids moléculaire
- 59 kDa
- ID gène
- 5551
- NCBI Accession
- NM_005041, NP_005032
- UniProt
- P14222
- Pathways
- Apoptose, Caspase Cascade in Apoptosis
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