SNCA anticorps (Middle Region)
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- Antigène Voir toutes SNCA Anticorps
- SNCA (Synuclein, alpha (SNCA))
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Épitope
- Middle Region
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Reactivité
- Humain, Rat, Souris, Boeuf (Vache), Chien, Mouton, Lapin, Cheval, Cobaye
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp SNCA est non-conjugé
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Application
- Western Blotting (WB)
- Séquence
- VTNVGGAVVT GVTAVAQKTV EGAGSIAAAT GFVKKDQLGK EGYQDYEPEA
- Homologie
- Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Sheep: 100%
- Attributs du produit
- This is a rabbit polyclonal antibody against SNCA. It was validated on Western Blot using a cell lysate as a positive control.
- Purification
- Affinity Purified
- Immunogène
- The immunogen is a synthetic peptide directed towards the middle region of human SNCA
- Top Product
- Discover our top product SNCA Anticorps primaire
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- Indications d'application
- Optimal working dilutions should be determined experimentally by the investigator.
- Commentaires
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Antigen size: 112 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freeze-thaw cycles.
- Stock
- -20 °C
- Stockage commentaire
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Antigène
- SNCA (Synuclein, alpha (SNCA))
- Autre désignation
- SNCA (SNCA Produits)
- Synonymes
- anticorps snca, anticorps MGC64356, anticorps LOC619283, anticorps NACP, anticorps alphaSYN, anticorps PARK1, anticorps PARK4, anticorps PD1, anticorps synuclein alpha L homeolog, anticorps alpha-synuclein, anticorps synuclein alpha, anticorps synuclein, alpha, anticorps snca.L, anticorps LOC619283, anticorps SNCA, anticorps Snca
- Sujet
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Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease.Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Two alternatively spliced transcripts of SNCA have been identified. Additional splicing may be present but the full-length nature of these variants has not been determined.
Alias Symbols: MGC110988, NACP, PARK1, PARK4, PD1
Protein Interaction Partner: NEDD4L, UBC, NEDD4, SNCA, GAPDH, HPRT1, CHMP5, KLK6, PARK7, LAMP2, CDC5, SLG1, PLK2, SAC7, TUS1, ROM2, MID2, Csnk2b, Lyn, Fgr, Csnk1g3, Syk, Rab5a, YWHAQ, ARPP19, RABAC1, TUBA1B, CALM, ACTA1, HIST2H3C, TUBB1, BDH2, USP47, SAP30BP, PELP1, SIN3A, Rab3a, ENC
Protein Size: 112 - Poids moléculaire
- 11 kDa
- ID gène
- 6622
- NCBI Accession
- NM_007308, NP_009292
- Pathways
- Synaptic Membrane, Regulation of G-Protein Coupled Receptor Protein Signaling, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process, Platelet-derived growth Factor Receptor Signaling, Negative Regulation of Transporter Activity, Regulation of long-term Neuronal Synaptic Plasticity
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