DKK4 anticorps (C-Term)
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- Antigène Voir toutes DKK4 Anticorps
- DKK4 (Dickkopf Homolog 4 (Xenopus Laevis) (DKK4))
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Épitope
- C-Term
- Reactivité
- Humain, Souris, Cobaye, Rat, Chien, Cheval, Lapin
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp DKK4 est non-conjugé
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Application
- Western Blotting (WB)
- Séquence
- RTSDCGPGLC CARHFWTKIC KPVLREGQVC SRRGHKDTAQ APEIFQRCDC
- Homologie
- Dog: 93%, Guinea Pig: 100%, Horse: 86%, Human: 100%, Mouse: 100%, Rabbit: 79%, Rat: 100%
- Attributs du produit
- This is a rabbit polyclonal antibody against Dkk4. It was validated on Western Blot.
- Purification
- Affinity Purified
- Top Product
- Discover our top product DKK4 Anticorps primaire
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- Indications d'application
- Optimal working dilutions should be determined experimentally by the investigator.
- Commentaires
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Antigen size: 221 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freeze-thaw cycles.
- Stock
- -20 °C
- Stockage commentaire
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Antigène
- DKK4 (Dickkopf Homolog 4 (Xenopus Laevis) (DKK4))
- Autre désignation
- Dkk4 (DKK4 Produits)
- Synonymes
- anticorps DKK-4, anticorps Dkk-4, anticorps RGD1563172, anticorps dickkopf WNT signaling pathway inhibitor 4, anticorps DKK4, anticorps Dkk4
- Sujet
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Dkk4 antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease.
Alias Symbols: Dkk-4, MGC25705
Protein Size: 221 - Poids moléculaire
- 24 kDa
- ID gène
- 234130
- NCBI Accession
- NM_145592, NP_663567
- UniProt
- Q8VEJ3
- Pathways
- Signalisation WNT
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