GAPVD1 anticorps (N-Term)

N° du produit ABIN2775423

Détail du produit anti-GAPVD1 anticorps

Antigène: GAPVD1 (GTPase Activating Protein and VPS9 Domains 1 (GAPVD1))

Épitope: N-Term

Reactivité: Humain, Souris, Rat, Chien, Lapin, Boeuf (Vache), Cobaye, Cheval, Poisson zèbre (Danio rerio)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GAPVD1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Séquence: FKLFSEGLFS AKLFLTATLH EPIMQLLVED EDHLETDPNK LIERFSPSQQ

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 93%

Attributs du produit: This is a rabbit polyclonal antibody against GAPVD1. It was validated on Western Blot and immunohistochemistry.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human GAPVD1

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 1487 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur GAPVD1

Antigène: GAPVD1 (GTPase Activating Protein and VPS9 Domains 1 (GAPVD1))

Autre désignation: GAPVD1 (GAPVD1 Produits)

Synonymes: anticorps zgc:92666, anticorps GAPEX5, anticorps RAP6, anticorps 2010005B09Rik, anticorps 4432404J10Rik, anticorps AW108497, anticorps Gapex-5, anticorps RME-6, anticorps mKIAA1521, anticorps RGD1307479, anticorps GTPase activating protein and VPS9 domains 1, anticorps GTPase activating protein and VPS9 domains 1 S homeolog, anticorps LOAG_00609, anticorps GAPVD1, anticorps gapvd1, anticorps gapvd1.S, anticorps Gapvd1

Sujet: GAPVD1 acts both as a GTPase-activating protein (GAP) and a guanine nucleotide exchange factor (GEF), and participates in various processes such as endocytosis, insulin receptor internalization or LC2A4/GLUT4 trafficking. It acts as a GEF for the Ras-related protein RAB31 by exchanging bound GDP for free GTP, leading to regulate LC2A4/GLUT4 trafficking. In the absence of insulin, it maintains RAB31 in an active state and promotes a futile cycle between LC2A4/GLUT4 storage vesicles and early endosomes, retaining LC2A4/GLUT4 inside the cells. Upon insulin stimulation, it is translocated to the plasma membrane, releasing LC2A4/GLUT4 from intracellular storage vesicles. It is also involved in EGFR trafficking and degradation, possibly by promoting EGFR ubiquitination and subsequent degradation by the proteasome. It has GEF activity for Rab5 and GAP activity for Ras.
Alias Symbols: DKFZP434C212, KIAA1521, MGC138847, MGC138848, RAP6, GAPEX5
Protein Interaction Partner: UBC, FOXK1, LRRC47, SF3A1, HNRNPR, IQGAP1, CCDC6, NR3C1, YWHAB, COPS2, SIRT7, ELAVL1, VAV2, RAD21, Csnk1e, CBL,
Protein Size: 1487

Poids moléculaire: 166 kDa

ID gène: 26130

NCBI Accession: NM_015635, NP_056450