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GNAS anticorps (N-Term)

GNAS Reactivité: Humain, Souris, Rat, Chien, Boeuf (Vache), Cheval, Lapin, Cobaye WB, IHC Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN2775542
  • Antigène Voir toutes GNAS Anticorps
    GNAS (GNAS Complex Locus (GNAS))
    Épitope
    • 17
    • 10
    • 8
    • 8
    • 7
    • 6
    • 5
    • 5
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reactivité
    • 85
    • 28
    • 24
    • 9
    • 7
    • 7
    • 5
    • 5
    • 4
    • 4
    • 4
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Humain, Souris, Rat, Chien, Boeuf (Vache), Cheval, Lapin, Cobaye
    Hôte
    • 80
    • 9
    • 1
    Lapin
    Clonalité
    • 82
    • 8
    Polyclonal
    Conjugué
    • 50
    • 9
    • 8
    • 7
    • 5
    • 5
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp GNAS est non-conjugé
    Application
    • 74
    • 42
    • 32
    • 18
    • 17
    • 9
    • 8
    • 3
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC)
    Séquence
    VYRATHRLLL LGAGESGKST IVKQMRILHV NGFNGEGGEE DPQAARSNSD
    Homologie
    Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 93%, Rat: 100%
    Attributs du produit
    This is a rabbit polyclonal antibody against GNAS. It was validated on Western Blot using a cell lysate as a positive control.
    Purification
    Affinity Purified
    Immunogène
    The immunogen is a synthetic peptide directed towards the N terminal region of human GNAS
    Top Product
    Discover our top product GNAS Anticorps primaire
  • Indications d'application
    Optimal working dilutions should be determined experimentally by the investigator.
    Commentaires

    Antigen size: 394 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Avoid repeated freeze-thaw cycles.
    Stock
    -20 °C
    Stockage commentaire
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Moreno-Smith, Lee, Lu, Nagaraja, He, Rupaimoole, Han, Jennings, Roh, Nishimura, Kang, Allen, Armaiz, Matsuo, Shahzad, Bottsford-Miller, Langley, Cole, Lutgendorf, Siddik, Sood: "Biologic effects of dopamine on tumor vasculature in ovarian carcinoma." dans: Neoplasia (New York, N.Y.), Vol. 15, Issue 5, pp. 502-10, (2013) (PubMed).

    Masyuk, Huang, Radtke, Gajdos, Splinter, Masyuk, Gradilone, LaRusso: "Ciliary subcellular localization of TGR5 determines the cholangiocyte functional response to bile acid signaling." dans: American journal of physiology. Gastrointestinal and liver physiology, Vol. 304, Issue 11, pp. G1013-24, (2013) (PubMed).

  • Antigène
    GNAS (GNAS Complex Locus (GNAS))
    Autre désignation
    GNAS (GNAS Produits)
    Synonymes
    anticorps AHO, anticorps C20orf45, anticorps GNAS1, anticorps GPSA, anticorps GSA, anticorps GSP, anticorps NESP, anticorps PHP1A, anticorps PHP1B, anticorps PHP1C, anticorps POH, anticorps GNAS, anticorps PORGSA1, anticorps G-alpha-S, anticorps 5530400H20Rik, anticorps A930027G11Rik, anticorps C130027O20Rik, anticorps Galphas, anticorps Gnas1, anticorps Gnasxl, anticorps Gsa, anticorps Nesp, anticorps Nespl, anticorps Oed-Sml, anticorps Oedsml, anticorps P1, anticorps P2, anticorps P3, anticorps G-alpha-s, anticorps gnas-a, anticorps Gnpas, anticorps Nesp55, anticorps gnal, anticorps Gnas, anticorps GNAS complex locus, anticorps guanine nucleotide-binding protein G(s) subunit alpha, anticorps GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus, anticorps GNAS complex locus S homeolog, anticorps neuroendocrine secretory protein 55-like, anticorps GNAS, anticorps LOC694289, anticorps LOC469986, anticorps Gnas, anticorps gnas.S, anticorps gnas, anticorps LOC100346323, anticorps LOC100442753, anticorps LOC100732436
    Sujet
    Mutations in GNAS gene result in pseudohypoparathyroidism type 1a, pseudohypoparathyroidism type 1b, Albright hereditary osteodystrophy, pseudopseudohypoparathyroidism, McCune-Albright syndrome, progressive osseus heteroplasia, polyostotic fibrous dysplasia of bone, and some pituitary tumors. This locus has a highly complex imprinted expression pattern. It gives rise to maternally, paternally, and biallelically expressed transcripts that are derived from four alternative promoters and 5' exons. Some transcripts contains a differentially methylated region (DMR) at their 5' exons, and this DMR is commonly found in imprinted genes and correlates with transcript expression. An antisense transcript exists, and this antisense transcript and one of the transcripts are paternally expressed, produce noncoding RNAs, and may regulate imprinting in this region. In addition, one of the transcripts contains a second overlapping ORF, which encodes a structurally unrelated protein - Alex. Alternative splicing of downstream exons is also observed, which results in different forms of the stimulatory G-protein alpha subunit, a key element of the classical signal transduction pathway linking receptor-ligand interactions with the activation of adenylyl cyclase and a variety of cellular reponses. Multiple transcript variants have been found for this gene, but the full-length nature and/or biological validity of some variants have not been determined. Mutations in this gene result in pseudohypoparathyroidism type 1a, pseudohypoparathyroidism type 1b, Albright hereditary osteodystrophy, pseudopseudohypoparathyroidism, McCune-Albright syndrome, progressive osseus heteroplasia, polyostotic fibrous dysplasia of bone, and some pituitary tumors.
    Alias Symbols: AHO, C20orf45, GNAS1, GPSA, GSA, GSP, MGC33735, PHP1A, PHP1B, POH, dJ309F20.1.1, dJ806M20.3.3, NESP, PHP1C
    Protein Interaction Partner: PANX1, AXIN1, UBC, FUS, OPTN, PTGIR, HLA-A, ADRB2, NUCB2, NUCB1, LAMTOR1, SLC25A12, GNAQ, GNA11, UBD, TBXA2R, GNB1, AVPR2, SUMO1, PCK1, Ric8b, GNG2, CALM1, Haus1, Trim69, Cbx1, RIC8A, TTC1, SNX13, ADCY5, CRHR1, PTGDR, TSHR, CAV3, HTR6, RGS2, ADCY6, VIPR1,
    Protein Size: 394
    Poids moléculaire
    46 kDa
    ID gène
    2778
    NCBI Accession
    NM_000516, NP_000507
    UniProt
    P63092
    Pathways
    Thyroid Hormone Synthesis, cAMP Metabolic Process, Myometrial Relaxation and Contraction, Embryonic Body Morphogenesis
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