HDAC9 anticorps (C-Term)

N° du produit ABIN2775576

Détail du produit anti-HDAC9 anticorps

Antigène: HDAC9 (Histone Deacetylase 9 (HDAC9))

Épitope: C-Term

Reactivité: Humain, Souris, Cobaye, Mouton

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp HDAC9 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Chromatin Immunoprecipitation (ChIP)

Séquence: QVGAVKVKEE PVDSDEDAQI QEMESGEQAA FMQQVIGKDL APGFVIKVII

Homologie: Guinea Pig: 100%, Human: 100%, Mouse: 100%, Sheep: 100%

Attributs du produit: This is a rabbit polyclonal antibody against HDAC9. It was validated on Western Blot and immunohistochemistry.

Purification: Protein A purified

Immunogène: The immunogen is a synthetic peptide directed towards the C terminal region of human HDAC9

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 590 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-HDAC9 (ABIN2775576)

Spallotta, Tardivo, Nanni, Rosati, Straino, Mai, Vecellio, Valente, Capogrossi, Farsetti, Martone, Bozzoni, Pontecorvi, Gaetano, Colussi: "Detrimental effect of class-selective histone deacetylase inhibitors during tissue regeneration following hindlimb ischemia." dans: The Journal of biological chemistry, Vol. 288, Issue 32, pp. 22915-29, (2013) (PubMed).

Milde, Oehme, Korshunov, Kopp-Schneider, Remke, Northcott, Deubzer, Lodrini, Taylor, von Deimling, Pfister, Witt: "HDAC5 and HDAC9 in medulloblastoma: novel markers for risk stratification and role in tumor cell growth." dans: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 16, Issue 12, pp. 3240-52, (2010) (PubMed).

Hang, Yang, Han, Cheng, Shang, Ashley, Zhou, Chang: "Chromatin regulation by Brg1 underlies heart muscle development and disease." dans: Nature, Vol. 466, Issue 7302, pp. 62-7, (2010) (PubMed).

Détails sur HDAC9

Antigène: HDAC9 (Histone Deacetylase 9 (HDAC9))

Autre désignation: HDAC9 (HDAC9 Produits)

Synonymes: anticorps HD7, anticorps HD7b, anticorps HD9, anticorps HDAC, anticorps HDAC7, anticorps HDAC7B, anticorps HDAC9B, anticorps HDAC9FL, anticorps HDRP, anticorps MITR, anticorps AV022454, anticorps D030072B18Rik, anticorps HD7B, anticorps Hdac7b, anticorps Mitr, anticorps mKIAA0744, anticorps hdac9, anticorps zgc:73392, anticorps TWIST, anticorps HDAC9, anticorps DKFZp459E171, anticorps HDA09, anticorps HISTONE DEACETYLASE, anticorps histone deacetylase 9, anticorps RGD1310748, anticorps RGD1563092, anticorps hdac9-A, anticorps histone deacetylase 9, anticorps histone deacetylase 9b, anticorps histone deacetylase 9 S homeolog, anticorps HDAC9, anticorps Hdac9, anticorps hdac9b, anticorps HDA9, anticorps hdac9.S

Sujet: Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. HDAC9 has sequence homology to members of the histone deacetylase family. The MITR protein lacks the histone deacetylase catalytic domain. It represses MEF2 activity through recruitment of multicomponent corepressor complexes that include CtBP and HDACs. HDAC9 may play a role in hematopoiesis.Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene has sequence homology to members of the histone deacetylase family. This gene is orthologous to the Xenopus and mouse MITR genes. The MITR protein lacks the histone deacetylase catalytic domain. It represses MEF2 activity through recruitment of multicomponent corepressor complexes that include CtBP and HDACs. This encoded protein may play a role in hematopoiesis. Multiple alternatively spliced transcripts have been described for this gene but the full-length nature of some of them has not been determined.
Alias Symbols: DKFZp779K1053, HD7, HDAC, HDAC7, HDAC7B, HDAC9B, HDAC9FL, HDRP, KIAA0744, MITR, HD9, HD7b
Protein Interaction Partner: NOP2, MKI67, EIF6, RCC1, ADAR, TOP1, TMPO, FIP1L1, CCAR2, TPX2, RBM14, ZC3H11A, HDAC9, NUP93, SMC3, H1FX, TPR, HINT1, CTBP1, BCL6, Zfp521, TRIM29, TP53, MAML1, SMARCA4, PARP1, CEBPB, H3F3A, RL2, CAMK1, YWHAE, HDAC1, SFN, MEF2B, ANKRA2, RFXANK, PKD1, SYK,
Protein Size: 590

Poids moléculaire: 65 kDa

ID gène: 9734

NCBI Accession: NM_014707, NP_055522

Pathways: Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development