RGS18 anticorps (N-Term)

N° du produit ABIN2775584

Détail du produit anti-RGS18 anticorps

Antigène: RGS18 (Regulator of G-Protein Signalling 18 (RGS18))

Épitope: N-Term

Reactivité: Humain, Rat, Souris, Chien, Cobaye, Cheval, Boeuf (Vache), Lapin

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp RGS18 est non-conjugé

Application: Western Blotting (WB)

Séquence: METTLLFFSQ INMCESKEKT FFKLIHGSGK EETSKEAKIR AKEKRNRLSL

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 86%, Horse: 93%, Human: 100%, Mouse: 93%, Rabbit: 93%, Rat: 100%

Attributs du produit: This is a rabbit polyclonal antibody against RGS18. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Protein A purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human RGS18

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 235 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur RGS18

Antigène: RGS18 (Regulator of G-Protein Signalling 18 (RGS18))

Autre désignation: RGS18 (RGS18 Produits)

Synonymes: anticorps RGS18, anticorps rgs18, anticorps RGS13, anticorps regulator of G-protein signaling 18, anticorps regulator of G protein signaling 18, anticorps RGS18, anticorps rgs18, anticorps LOC100224724, anticorps Rgs18

Sujet: RGS18 is a member of the regulator of G-protein signaling family. This protein is contains a conserved, 120 amino acid motif called the RGS domain. The protein attenuates the signaling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal.This gene encodes a member of the regulator of G-protein signaling family. This protein is contains a conserved, 120 amino acid motif called the RGS domain. The protein attenuates the signaling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.
Alias Symbols: RP11-142L4.1, RGS13
Protein Interaction Partner: APP, GNAQ, GNAI3, GNAI2, GNAI1,
Protein Size: 235

Poids moléculaire: 26 kDa

ID gène: 64407

NCBI Accession: NM_130782, NP_570138

UniProt: Q9NS28

Pathways: Myometrial Relaxation and Contraction, Regulation of G-Protein Coupled Receptor Protein Signaling