KEAP1 anticorps (C-Term)

N° du produit ABIN2775979

Détail du produit anti-KEAP1 anticorps

Antigène: KEAP1 (Kelch-Like ECH-Associated Protein 1 (KEAP1))

Épitope: C-Term

Reactivité: Humain, Souris, Rat, Lapin, Boeuf (Vache), Chien, Cheval, Cobaye, Poisson zèbre (Danio rerio)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp KEAP1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Séquence: TWTFVAPMKH RRSALGITVH QGRIYVLGGY DGHTFLDSVE CYDPDTDTWS

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 93%

Attributs du produit: This is a rabbit polyclonal antibody against KEAP1. It was validated on Western Blot and immunohistochemistry.

Purification: Protein A purified

Immunogène: The immunogen is a synthetic peptide directed towards the C terminal region of human KEAP1

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 624 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-KEAP1 (ABIN2775979)

Konishi, Baumgarten, Ishida, Saitoh, Anker, Springer: "Protein levels in Keap1-Nrf2 system in human failing heart." dans: International journal of cardiology, Vol. 225, pp. 62-64, (2016) (PubMed).

Détails sur KEAP1

Antigène: KEAP1 (Kelch-Like ECH-Associated Protein 1 (KEAP1))

Autre désignation: KEAP1 (KEAP1 Produits)

Synonymes: anticorps INrf2, anticorps KLHL19, anticorps INRF2, anticorps mKIAA0132, anticorps Inrf2, anticorps fb36f11, anticorps keap1, anticorps wu:fb36f11, anticorps KEAP1, anticorps klhl19, anticorps zgc:171654, anticorps kelch like ECH associated protein 1, anticorps kelch-like ECH-associated protein 1, anticorps Kelch-like ECH-associated protein 1, anticorps kelch-like ECH-associated protein 1a, anticorps kelch like ECH associated protein 1 L homeolog, anticorps kelch-like ECH-associated protein 1b, anticorps KEAP1, anticorps Keap1, anticorps keap1a, anticorps keap1, anticorps keap1.L, anticorps keap1b

Sujet: KEAP1 contains KELCH-1 like domains, as well as a BTB/POZ domain. Kelch-like ECH-associated protein 1 interacts with NF-E2-related factor 2 in a redox-sensitive manner and the dissociation of the proteins in the cytoplasm is followed by transportation of NF-E2-related factor 2 to the nucleus. This interaction results in the expression of the catalytic subunit of gamma-glutamylcysteine synthetase.This gene encodes a protein containing KELCH-1 like domains, as well as a BTB/POZ domain. Kelch-like ECH-associated protein 1 interacts with NF-E2-related factor 2 in a redox-sensitive manner and the dissociation of the proteins in the cytoplasm is followed by transportation of NF-E2-related factor 2 to the nucleus. This interaction results in the expression of the catalytic subunit of gamma-glutamylcysteine synthetase. Two alternatively spliced transcript variants encoding the same isoform have been found for this gene.
Alias Symbols: INrf2, KIAA0132, KLHL19, MGC10630, MGC1114, MGC20887, MGC4407, MGC9454
Protein Interaction Partner: OXR1, ZSCAN32, LSM3, KLHL3, FBXW11, MAPKBP1, NUDT4, DPP3, RBX1, ATG5, SQSTM1, PTMA, PRKAG1, NFE2L2, MAD2L1, GYPA, ETF1, BCL2, CUL3, RECK, UBC, PGAM5, FAM117B, WDR83, CCNB1IP1, HSP90AA1, XPO1, MCMBP, KEAP1, SLK, MCM3, IKBKB, AMER1, GPRASP2, PRKCE, NFE2L1,
Protein Size: 624

Poids moléculaire: 70 kDa

ID gène: 9817

NCBI Accession: NM_203500, NP_987096

UniProt: Q14145

Pathways: Maintenance of Protein Location