CREM anticorps (N-Term)

N° du produit ABIN2776016

Détail du produit anti-CREM anticorps

Antigène: CREM (CAMP Responsive Element Modulator (CREM))

Épitope: N-Term

Reactivité: Humain, Souris, Rat, Chien, Boeuf (Vache), Cobaye, Cheval, Lapin, Mouton, Poisson zèbre (Danio rerio), Chévre

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CREM est non-conjugé

Application: Western Blotting (WB)

Séquence: MAAATGDMPT YQIRAPTAAL PQGVVMAASP GSLHSPQQLA EEATRKRELR

Homologie: Cow: 100%, Dog: 100%, Goat: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Sheep: 100%, Zebrafish: 79%

Attributs du produit: This is a rabbit polyclonal antibody against CREM. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Protein A purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human CREM

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 120 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-CREM (ABIN2776016)

Sunahori, Juang, Tsokos: "Methylation status of CpG islands flanking a cAMP response element motif on the protein phosphatase 2Ac alpha promoter determines CREB binding and activity." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 182, Issue 3, pp. 1500-8, (2009) (PubMed).

Lazrek, Goffard, Schanen, Karquel, Bocket, Lion, Devaux, Hedouin, Gosset, Hober: "Detection of hepatitis C virus antibodies and RNA among medicolegal autopsy cases in Northern France." dans: Diagnostic microbiology and infectious disease, Vol. 55, Issue 1, pp. 55-8, (2006) (PubMed).

Détails sur CREM

Antigène: CREM (CAMP Responsive Element Modulator (CREM))

Autre désignation: CREM (CREM Produits)

Synonymes: anticorps CREM, anticorps ICER, anticorps CREM-2, anticorps hCREM-2, anticorps ICERI, anticorps Icer, anticorps cAMP responsive element modulator, anticorps CREM, anticorps Crem

Sujet: CREM is a bZIP transcription factor that binds to the cAMP responsive element found in many viral and cellular promoters. It is an important component of cAMP-mediated signal transduction during the spermatogenetic cycle, as well as other complex processes. Alternative promoter and translation initiation site usage allows this gene to exert spatial and temporal specificity to cAMP responsiveness. Multiple alternatively spliced transcript variants encoding several different isoforms have been found for this gene, with some of them functioning as activators and some as repressors of transcription.
Alias Symbols: ICER, CREM-2, hCREM-2
Protein Interaction Partner: CREB1, PIAS3, CASP8AP2, UBE2I, UBC, SP100, ATXN1, EMP3, HHV8GK18_gp81, MAPK3, CREB3L4, HDAC1, CREB3L1, TAF4, CAMK2D, GSK3A, FHL5, GSK3B, KCNIP3, CAMK2G, PRKACA, CSNK1A1, CREBBP, TBP, PRKCA, SPI1, CREM, ATF1, CDC34, CDK1, CSNK2A2, CSNK2A1, CD34,
Protein Size: 120

Poids moléculaire: 13 kDa

ID gène: 1390

NCBI Accession: NM_182717, NP_874386

UniProt: O75519

Pathways: Retinoic Acid Receptor Signaling Pathway