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MBD4 anticorps (Middle Region)

MBD4 Reactivité: Humain, Cobaye WB, ChIP Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN2776028
  • Antigène Voir toutes MBD4 Anticorps
    MBD4 (Methyl-CpG Binding Domain Protein 4 (MBD4))
    Épitope
    • 9
    • 9
    • 8
    • 6
    • 6
    • 2
    • 1
    • 1
    • 1
    • 1
    Middle Region
    Reactivité
    • 32
    • 5
    • 3
    Humain, Cobaye
    Hôte
    • 31
    • 1
    • 1
    Lapin
    Clonalité
    • 32
    • 1
    Polyclonal
    Conjugué
    • 16
    • 4
    • 4
    • 3
    • 3
    • 3
    Cet anticorp MBD4 est non-conjugé
    Application
    • 26
    • 24
    • 10
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), Chromatin Immunoprecipitation (ChIP)
    Séquence
    CSEQKTSGII NKFCSAKDSE HNEKYEDTFL ESEEIGTKVE VVERKEHLHT
    Homologie
    Guinea Pig: 83%, Human: 100%
    Attributs du produit
    This is a rabbit polyclonal antibody against MBD4. It was validated on Western Blot using a cell lysate as a positive control.
    Purification
    Affinity Purified
    Immunogène
    The immunogen is a synthetic peptide directed towards the middle region of human MBD4
    Top Product
    Discover our top product MBD4 Anticorps primaire
  • Indications d'application
    Optimal working dilutions should be determined experimentally by the investigator.
    Commentaires

    Antigen size: 580 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Avoid repeated freeze-thaw cycles.
    Stock
    -20 °C
    Stockage commentaire
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Antigène
    MBD4 (Methyl-CpG Binding Domain Protein 4 (MBD4))
    Autre désignation
    MBD4 (MBD4 Produits)
    Synonymes
    anticorps MED1, anticorps Med1, anticorps methyl-CpG binding domain 4, DNA glycosylase, anticorps methyl-CpG binding domain protein 4, anticorps methyl-CpG binding domain 4 DNA glycosylase, anticorps MBD4, anticorps Mbd4
    Sujet
    MBD4 is involved with DNA methylation. DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD3 comprise a family of nuclear proteins related by??he presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MBD4 may function to mediate the biological consequences of the methylation signal. In addition, MBD4 has protein sequence similarity to bacterial DNA repair enzymes and thus may have some function in DNA repair. Further, MBD4 gene mutations are detected in tumors with primary microsatellite-instability (MSI), a form of genomic instability associated with defective DNA mismatch repair, and MBD4 gene meets 4 of 5 criteria of a bona fide MIS target gene.DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MBD4 may function to mediate the biological consequences of the methylation signal. In addition, MBD4 has protein sequence similarity to bacterial DNA repair enzymes and thus may have some function in DNA repair. Further, MBD4 gene mutations are detected in tumors with primary microsatellite-instability (MSI), a form of genomic instability associated with defective DNA mismatch repair, and MBD4 gene meets 4 of 5 criteria of a bona fide MIS target gene. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
    Alias Symbols: MED1
    Protein Interaction Partner: KDM1A, SUV39H1, HTT, FAS, SUMO2, UBC, CDCA2, Trim27, FADD, MLH1, CSNK2B, DNMT3B, SIN3A, HDAC1,
    Protein Size: 580
    Poids moléculaire
    66 kDa
    ID gène
    8930
    NCBI Accession
    NM_003925, NP_003916
    UniProt
    O95243
    Pathways
    Réparation de l'ADN
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