KCNK3 anticorps (C-Term)

N° du produit ABIN2776142

Détail du produit anti-KCNK3 anticorps

Antigène: KCNK3 (Potassium Channel, Subfamily K, Member 3 (KCNK3))

Épitope: C-Term

Reactivité: Rat, Humain, Souris, Chien, Mouton, Boeuf (Vache), Cobaye, Lapin

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp KCNK3 est non-conjugé

Application: Western Blotting (WB)

Séquence: TCVEQSHSSP GGGGRYSDTP SRRCLCSGAP RSAISSVSTG LHSLSTFRGL

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Human: 100%, Mouse: 100%, Rabbit: 86%, Rat: 100%, Sheep: 100%

Attributs du produit: This is a rabbit polyclonal antibody against KCNK3. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Protein A purified

Immunogène: The immunogen is a synthetic peptide directed towards the C terminal region of human KCNK3

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 394 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-KCNK3 (ABIN2776142)

Donner, Schullenberg, Geduldig, Hüning, Mersmann, Zacharowski, Kovacevic, Decking, Aller, Schmidt: "Functional role of TASK-1 in the heart: studies in TASK-1-deficient mice show prolonged cardiac repolarization and reduced heart rate variability." dans: Basic research in cardiology, Vol. 106, Issue 1, pp. 75-87, (2010) (PubMed).

Nogueira, Gerry, Mantero, Mariniello, Rainey: "The role of TASK1 in aldosterone production and its expression in normal adrenal and aldosterone-producing adenomas." dans: Clinical endocrinology, Vol. 73, Issue 1, pp. 22-9, (2010) (PubMed).

Détails sur KCNK3

Antigène: KCNK3 (Potassium Channel, Subfamily K, Member 3 (KCNK3))

Autre désignation: KCNK3 (KCNK3 Produits)

Synonymes: anticorps si:dkey-164m15.1, anticorps K2p3.1, anticorps OAT1, anticorps PPH4, anticorps TASK, anticorps TASK-1, anticorps TBAK1, anticorps cTBAK-1, anticorps Task-1, anticorps rTASK, anticorps KCNK3, anticorps potassium channel, subfamily K, member 3a, anticorps potassium two pore domain channel subfamily K member 3, anticorps potassium channel, subfamily K, member 3, anticorps kcnk3a, anticorps KCNK3, anticorps Kcnk3

Sujet: KCNK3 encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. The gene product is an outwardly rectifying channel that is sensitive to changes in extracellular pH and is inhibited by extracellular acidification. Also referred to as an acid-sensitive potassium channel, it is activated by the anesthetics halothane and isoflurane. Although three transcripts are detected in northern blots, there is currently no sequence available to confirm transcript variants for this gene.
Alias Symbols: TASK, TBAK1, K2p3.1, TASK-1
Protein Interaction Partner: YWHAB, COPB1, YWHAG, YWHAE, SFN, YWHAZ, YWHAQ, S100A10, YWHAH,
Protein Size: 394

Poids moléculaire: 43 kDa

ID gène: 3777

NCBI Accession: NM_002246, NP_002237

UniProt: O14649