TRPM4 anticorps (N-Term)
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- Antigène Voir toutes TRPM4 Anticorps
- TRPM4 (Transient Receptor Potential Cation Channel, Subfamily M, Member 4 (TRPM4))
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Épitope
- N-Term
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Reactivité
- Humain, Rat, Souris, Boeuf (Vache), Chien, Cheval, Cobaye
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp TRPM4 est non-conjugé
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Application
- Western Blotting (WB)
- Séquence
- ELLTVYSSED GSEEFETIVL KALVKACGSS EASAYLDELR LAVAWNRVDI
- Homologie
- Cow: 79%, Dog: 86%, Guinea Pig: 93%, Horse: 86%, Human: 100%, Mouse: 100%, Rat: 100%
- Attributs du produit
- This is a rabbit polyclonal antibody against TRPM4. It was validated on Western Blot using a cell lysate as a positive control.
- Purification
- Affinity Purified
- Immunogène
- The immunogen is a synthetic peptide directed towards the N terminal region of human TRPM4
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- Indications d'application
- Optimal working dilutions should be determined experimentally by the investigator.
- Commentaires
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Antigen size: 1214 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freeze-thaw cycles.
- Stock
- -20 °C
- Stockage commentaire
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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KCa3.1 and TRPM7 channels at the uropod regulate migration of activated human T cells." dans: PLoS ONE, Vol. 7, Issue 8, pp. e43859, (2012) (PubMed).
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KCa3.1 and TRPM7 channels at the uropod regulate migration of activated human T cells." dans: PLoS ONE, Vol. 7, Issue 8, pp. e43859, (2012) (PubMed).
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- Antigène
- TRPM4 (Transient Receptor Potential Cation Channel, Subfamily M, Member 4 (TRPM4))
- Autre désignation
- TRPM4 (TRPM4 Produits)
- Synonymes
- anticorps PFHB1B, anticorps TRPM4B, anticorps LTrpC-4, anticorps Mls2s, anticorps 1110030C19Rik, anticorps AW047689, anticorps LTRPC4, anticorps TRPM4, anticorps transient receptor potential cation channel subfamily M member 4, anticorps transient receptor potential cation channel, subfamily M, member 4, anticorps TRPM4, anticorps Trpm4
- Sujet
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TRPM4 is a calcium-activated non selective (CAN) cation channel that mediates membrane depolarization. While it is activated by increase in intracellular Ca2+, it is impermeable to it. TRPM4 mediates transport of monovalent cations (Na+ > K+ > Cs+ > Li+), leading to depolarize the membrane. It thereby plays a central role in cadiomyocytes, neurons from entorhinal cortex, dorsal root and vomeronasal neurons, endocrine pancreas cells, kidney epithelial cells, cochlea hair cells etc. Participates in T-cell activation by modulating Ca2+ oscillations after T lymphocyte activation, which is required for NFAT-dependent IL2 production. TRPM4 is involved in myogenic constriction of cerebral arteries. It controls insulin secretion in pancreatic beta-cells. TRPM4 may also be involved in pacemaking or could cause irregular electrical activity under conditions of Ca2+ overload.
Alias Symbols: FLJ20041, TRPM4B, PFHB1B
Protein Interaction Partner: FUS, UBC, TRPM4,
Protein Size: 1214 - Poids moléculaire
- 134 kDa
- ID gène
- 54795
- NCBI Accession
- NM_017636, NP_060106
- UniProt
- Q8TD43
- Pathways
- Regulation of Leukocyte Mediated Immunity, Production of Molecular Mediator of Immune Response
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