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GABRE anticorps (Middle Region)

GABRE Reactivité: Humain, Cobaye, Souris, Lapin, Rat WB Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN2776248
  • Antigène Voir toutes GABRE Anticorps
    GABRE (gamma-aminobutyric Acid (GABA) A Receptor, epsilon (GABRE))
    Épitope
    • 15
    • 8
    • 8
    • 6
    • 1
    • 1
    • 1
    Middle Region
    Reactivité
    Humain, Cobaye, Souris, Lapin, Rat
    Hôte
    • 39
    • 1
    Lapin
    Clonalité
    • 39
    • 1
    Polyclonal
    Conjugué
    • 10
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp GABRE est non-conjugé
    Application
    • 19
    • 16
    • 13
    • 13
    • 4
    • 3
    • 1
    • 1
    Western Blotting (WB)
    Séquence
    KNSWKLFQFD FTGVSNKTEI ITTPVGDFMV MTIFFNVSRR FGYVAFQNYV
    Homologie
    Guinea Pig: 79%, Human: 100%, Mouse: 85%, Rabbit: 86%, Rat: 92%
    Attributs du produit
    This is a rabbit polyclonal antibody against GABRE. It was validated on Western Blot using a cell lysate as a positive control.
    Purification
    Affinity Purified
    Immunogène
    The immunogen is a synthetic peptide directed towards the middle region of human GABRE
    Top Product
    Discover our top product GABRE Anticorps primaire
  • Indications d'application
    Optimal working dilutions should be determined experimentally by the investigator.
    Commentaires

    Antigen size: 393 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Avoid repeated freeze-thaw cycles.
    Stock
    -20 °C
    Stockage commentaire
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Fatemi, Folsom, Rooney, Thuras: "Expression of GABAA ?2-, ?1- and ?-receptors are altered significantly in the lateral cerebellum of subjects with schizophrenia, major depression and bipolar disorder." dans: Translational psychiatry, Vol. 3, pp. e303, (2013) (PubMed).

    Hengen, Nelson, Stang, Johnson, Crader, Watters, Mitchell, Behan: "Increased GABA(A) receptor ?-subunit expression on ventral respiratory column neurons protects breathing during pregnancy." dans: PLoS ONE, Vol. 7, Issue 1, pp. e30608, (2012) (PubMed).

    Hengen, Gomez, Stang, Johnson, Behan: "Changes in ventral respiratory column GABAaR ?- and ?-subunits during hibernation mediate resistance to depression by EtOH and pentobarbital." dans: American journal of physiology. Regulatory, integrative and comparative physiology, Vol. 300, Issue 2, pp. R272-83, (2011) (PubMed).

  • Antigène
    GABRE (gamma-aminobutyric Acid (GABA) A Receptor, epsilon (GABRE))
    Autre désignation
    GABRE (GABRE Produits)
    Synonymes
    anticorps GABRE, anticorps gamma-aminobutyric acid type A receptor epsilon subunit, anticorps gamma-aminobutyric acid (GABA) A receptor, subunit epsilon, anticorps GABRE, anticorps Gabre
    Sujet
    GABRE belongs to the ligand-gated ionic channel (TC 1.A.9) family. It encodes the gamma-aminobutyric acid (GABA) A receptor which is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. This gene encodes an epsilon subunit. It is mapped to chromosome Xq28 in a cluster comprised of genes encoding alpha 3, beta 4 and theta subunits of the same receptor. Alternatively spliced transcript variants encoding different isoforms have been identified.
    Protein Size: 393
    Poids moléculaire
    43 kDa
    ID gène
    2564
    NCBI Accession
    NM_021984, NP_068819
    Pathways
    Synaptic Membrane
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