KCNQ2 anticorps (Middle Region)
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- Antigène Voir toutes KCNQ2 Anticorps
- KCNQ2 (Potassium Voltage-Gated Channel, KQT-Like Subfamily, Member 2 (KCNQ2))
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Épitope
- Middle Region
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Reactivité
- Rat, Humain, Souris, Chien, Boeuf (Vache), Cobaye, Cheval, Lapin, Poisson zèbre (Danio rerio)
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp KCNQ2 est non-conjugé
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Application
- Western Blotting (WB), Immunohistochemistry (IHC)
- Séquence
- GNVFATSALR SLRFLQILRM IRMDRRGGTW KLLGSVVYAH SKELVTAWYI
- Homologie
- Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 93%, Rat: 100%, Zebrafish: 93%
- Attributs du produit
- This is a rabbit polyclonal antibody against KCNQ2. It was validated on Western Blot and immunohistochemistry.
- Purification
- Protein A purified
- Immunogène
- The immunogen is a synthetic peptide directed towards the middle region of human KCNQ2
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- Indications d'application
- Optimal working dilutions should be determined experimentally by the investigator.
- Commentaires
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Antigen size: 393 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freeze-thaw cycles.
- Stock
- -20 °C
- Stockage commentaire
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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Membrane microdomain determines the specificity of receptor-mediated modulation of Kv7/M potassium currents." dans: Neuroscience, Vol. 254, pp. 70-9, (2013) (PubMed).
: "A novel mutation in KCNQ2 gene causes benign familial neonatal convulsions in a Chinese family." dans: Journal of the neurological sciences, Vol. 221, Issue 1-2, pp. 31-4, (2004) (PubMed).
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Membrane microdomain determines the specificity of receptor-mediated modulation of Kv7/M potassium currents." dans: Neuroscience, Vol. 254, pp. 70-9, (2013) (PubMed).
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- Antigène
- KCNQ2 (Potassium Voltage-Gated Channel, KQT-Like Subfamily, Member 2 (KCNQ2))
- Autre désignation
- KCNQ2 (KCNQ2 Produits)
- Synonymes
- anticorps BFNC, anticorps BFNS1, anticorps EBN, anticorps EBN1, anticorps EIEE7, anticorps ENB1, anticorps HNSPC, anticorps KCNA11, anticorps KV7.2, anticorps KVEBN1, anticorps KQT2, anticorps Nmf134, anticorps mKQT2.3, anticorps mKQT2.4, anticorps zgc:171872, anticorps potassium voltage-gated channel subfamily Q member 2, anticorps potassium voltage-gated channel, subfamily Q, member 2, anticorps potassium voltage-gated channel subfamily KQT member 2, anticorps potassium voltage-gated channel, KQT-like subfamily, member 2a, anticorps KCNQ2, anticorps Kcnq2, anticorps LOC100537363, anticorps kcnq2a
- Sujet
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The M channel is a slowly activating and deactivating potassium channel that plays a critical role in the regulation of neuronal excitability. The M channel is formed by the association of the protein encoded by the KCNQ2 gene and a related protein encoded by the KCNQ3 gene, both integral membrane proteins. M channel currents are inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. Defects in KCNQ2 are a cause of benign familial neonatal convulsions type 1 (BFNC), also known as epilepsy, benign neonatal type 1 (EBN1).
Alias Symbols: EBN, BFNC, EBN1, ENB1, BFNS1, EIEE7, HNSPC, KV7.2, KCNA11, KVEBN1
Protein Interaction Partner: ARIH2, KCNQ3, PRKCA, CALM3, CALM1, CALM2, KCNQ1,
Protein Size: 393 - Poids moléculaire
- 43 kDa
- ID gène
- 3785
- NCBI Accession
- NM_172109, NP_742107
- UniProt
- Q5VYU0
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