HSBP1 anticorps (N-Term)

N° du produit ABIN2776380

Détail du produit anti-HSBP1 anticorps

Antigène: HSBP1 (Heat Shock Factor Binding Protein 1 (HSBP1))

Épitope: N-Term

Reactivité: Humain, Souris, Rat, Porc, Boeuf (Vache), Lapin, Chien, Poisson zèbre (Danio rerio), Cheval, Cobaye

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp HSBP1 est non-conjugé

Application: Western Blotting (WB)

Séquence: AETDPKTVQD LTSVVQTLLQ QMQDKFQTMS DQIIGRIDDM SSRIDDLEKN

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 79%, Pig: 100%, Rabbit: 100%, Rat: 93%, Zebrafish: 86%

Attributs du produit: This is a rabbit polyclonal antibody against HSBP1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human HSBP1

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 76 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-HSBP1 (ABIN2776380)

Tai, McFall, Huang, Demeler, Fox, Brubaker, Radhakrishnan, Morimoto: "Structure-function analysis of the heat shock factor-binding protein reveals a protein composed solely of a highly conserved and dynamic coiled-coil trimerization domain." dans: The Journal of biological chemistry, Vol. 277, Issue 1, pp. 735-45, (2002) (PubMed).

Détails sur HSBP1

Antigène: HSBP1 (Heat Shock Factor Binding Protein 1 (HSBP1))

Autre désignation: HSBP1 (HSBP1 Produits)

Synonymes: anticorps HSBP1, anticorps npc-a-13, anticorps NPC-A-13, anticorps hsbp1, anticorps hsbp1a, anticorps 0610007A03Rik, anticorps AA408769, anticorps Hsp25, anticorps zgc:73224, anticorps heat shock factor binding protein 1 like 1, anticorps heat shock factor binding protein 1, anticorps Heat shock factor binding protein 1, anticorps heat shock factor binding protein 1 S homeolog, anticorps heat shock factor binding protein 1 L homeolog, anticorps heat shock factor binding protein 1b, anticorps HSBP1L1, anticorps HSBP1, anticorps Bm1_07370, anticorps hsbp1.S, anticorps hsbp1, anticorps hsbp1.L, anticorps Hsbp1, anticorps hsbp1b

Sujet: The heat-shock response is elicited by exposure of cells to thermal and chemical stress and through the activation of HSFs (heat shock factors) results in the elevated expression of heat-shock induced genes. Heat shock factor binding protein 1 (HSBP1), is a 76-amino-acid protein that binds to heat shock factor 1(HSF1), which is a transcription factor involved in the HS response. During HS response, HSF1 undergoes conformational transition from an inert non-DNA-binding monomer to active functional trimers. HSBP1 is nuclear-localized and interacts with the active trimeric state of HSF1 to negatively regulate HSF1 DNA-binding activity. Overexpression of HSBP1 in mammalian cells represses the transactivation activity of HSF1. When overexpressed in C.elegans HSBP1 has severe effects on survival of the animals after thermal and chemical stress consistent with a role of HSBP1 as a negative regulator of heat shock response.The heat-shock response is elicited by exposure of cells to thermal and chemical stress and through the activation of HSFs (heat shock factors) results in the elevated expression of heat-shock induced genes. Heat shock factor binding protein 1 (HSBP1), is a 76-amino-acid protein that binds to heat shock factor 1(HSF1), which is a transcription factor involved in the HS response. During HS response, HSF1 undergoes conformational transition from an inert non-DNA-binding monomer to active functional trimers. HSBP1 is nuclear-localized and interacts with the active trimeric state of HSF1 to negatively regulate HSF1 DNA-binding activity. Overexpression of HSBP1 in mammalian cells represses the transactivation activity of HSF1. When overexpressed in C.elegans HSBP1 has severe effects on survival of the animals after thermal and chemical stress consistent with a role of HSBP1 as a negative regulator of heat shock response.
Alias Symbols: DKFZp686D1664, DKFZp686O24200, NPC-A-13
Protein Interaction Partner: NOTCH2NL, KRTAP10-3, KRTAP10-7, LNX1, KIAA1217, CCHCR1, CCDC53, SDCBP, KIFC3, HSBP1, UBC, VCP, RRBP1, RB1CC1, HSF1, HSPA1A, HSPA4,
Protein Size: 76

Poids moléculaire: 8 kDa

ID gène: 3281

NCBI Accession: NM_001537, NP_001528

UniProt: O75506

Pathways: SARS-CoV-2 Protein Interactome