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ZIC2 anticorps (C-Term)

ZIC2 Reactivité: Humain, Rat, Souris, Cobaye WB, IHC Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN2776475
  • Antigène Voir toutes ZIC2 Anticorps
    ZIC2
    Épitope
    • 15
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reactivité
    • 18
    • 15
    • 13
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Humain, Rat, Souris, Cobaye
    Hôte
    • 31
    • 2
    • 1
    Lapin
    Clonalité
    • 32
    • 2
    Polyclonal
    Conjugué
    • 11
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp ZIC2 est non-conjugé
    Application
    • 23
    • 13
    • 13
    • 8
    • 7
    • 3
    • 2
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC)
    Séquence
    EPQSSSNLSP AAAAAAAAAA AAAAAVSAVH RGGGSGSGGA GGGSGGGSGS
    Homologie
    Guinea Pig: 87%, Human: 100%, Mouse: 85%, Rat: 92%
    Attributs du produit
    This is a rabbit polyclonal antibody against ZIC2. It was validated on Western Blot and immunohistochemistry.
    Purification
    Affinity Purified
    Immunogène
    The immunogen is a synthetic peptide directed towards the C terminal region of human ZIC2
  • Indications d'application
    Optimal working dilutions should be determined experimentally by the investigator.
    Commentaires

    Antigen size: 532 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Avoid repeated freeze-thaw cycles.
    Stock
    -20 °C
    Stockage commentaire
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Toth, Schiffmann, Hube-Magg, Büscheck, Höflmayer, Weidemann, Lebok, Fraune, Minner, Schlomm, Sauter, Plass, Assenov, Simon, Meiners, Gerhäuser: "Random forest-based modelling to detect biomarkers for prostate cancer progression." dans: Clinical epigenetics, Vol. 11, Issue 1, pp. 148, (2020) (PubMed).

    Inaguma, Ito, Riku, Ikeda, Kasai: "Addiction of pancreatic cancer cells to zinc-finger transcription factor ZIC2." dans: Oncotarget, Vol. 6, Issue 29, pp. 28257-68, (2015) (PubMed).

    Zhu, Wang, He, Huang, Du, Zhang, Yan, Xia, Ye, Wang, Hao, Wu, Fan: "ZIC2-dependent OCT4 activation drives self-renewal of human liver cancer stem cells." dans: The Journal of clinical investigation, Vol. 125, Issue 10, pp. 3795-808, (2015) (PubMed).

    McCampbell, Truong, Broom, Allchorne, Gable, Cutler, Mattson, Woolf, Frosch, Harmon, Dunn, Brown: "Mutant SPTLC1 dominantly inhibits serine palmitoyltransferase activity in vivo and confers an age-dependent neuropathy." dans: Human molecular genetics, Vol. 14, Issue 22, pp. 3507-21, (2005) (PubMed).

  • Antigène
    ZIC2
    Autre désignation
    ZIC2 (ZIC2 Produits)
    Synonymes
    anticorps HPE5, anticorps Ku, anticorps cb851, anticorps fb26a03, anticorps wu:fb26a03, anticorps zic2, anticorps zic2.1, anticorps hpe5, anticorps hm:zeh0655, anticorps id:ibd5017, anticorps zic2.2, anticorps zic2l, anticorps Zic family member 2, anticorps zinc finger protein of the cerebellum 2, anticorps zic family member 2 (odd-paired homolog, Drosophila), a, anticorps Zic family member 2 L homeolog, anticorps zic family member 2 (odd-paired homolog, Drosophila) b, anticorps ZIC2, anticorps Zic2, anticorps zic2a, anticorps zic2.L, anticorps zic2b
    Sujet
    ZIC2 is a member of the ZIC family of C2H2-type zinc finger proteins. This protein functions as a transcriptional repressor and may regulate tissue specific expression of dopamine receptor D1. Mutations in this gene cause holoprosencephaly type 5. Holoprosencephaly is the most common structural anomaly of the human brain. A polyhistidine tract polymorphism in this gene may be associated with increased risk of neural tube defects.This gene encodes a member of the ZIC family of C2H2-type zinc finger proteins. This protein functions as a transcriptional repressor and may regulate tissue specific expression of dopamine receptor D1. Mutations in this gene cause holoprosencephaly type 5. Holoprosencephaly is the most common structural anomaly of the human brain. A polyhistidine tract polymorphism in this gene may be associated with increased risk of neural tube defects. This gene is closely linked to a gene encoding zinc finger protein of the cerebellum 5, a related family member on chromosome 13.
    Alias Symbols: HPE5
    Protein Interaction Partner: SUMO1, ELAVL1, GLI3, GLI2, GLI1, RNF180, UBC,
    Protein Size: 532
    Poids moléculaire
    55 kDa
    ID gène
    7546
    NCBI Accession
    NM_007129, NP_009060
    UniProt
    O95409
    Pathways
    Tube Formation
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