DGCR8 anticorps (N-Term)
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- Antigène Voir toutes DGCR8 Anticorps
- DGCR8 (DiGeorge Syndrome Critical Region Gene 8 (DGCR8))
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Épitope
- N-Term
- Reactivité
- Humain, Souris, Rat, Boeuf (Vache), Chien, Cheval, Cobaye, Lapin, Poisson zèbre (Danio rerio)
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp DGCR8 est non-conjugé
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Application
- Western Blotting (WB), Immunohistochemistry (IHC)
- Séquence
- DKKDEENELD QEKRVEYAVL DELEDFTDNL ELDEEGAGGF TAKAIVQRDR
- Homologie
- Cow: 85%, Dog: 100%, Guinea Pig: 100%, Horse: 93%, Human: 100%, Mouse: 100%, Rabbit: 93%, Rat: 100%, Zebrafish: 77%
- Attributs du produit
- This is a rabbit polyclonal antibody against DGCR8. It was validated on Western Blot using a cell lysate as a positive control.
- Purification
- Affinity Purified
- Immunogène
- The immunogen is a synthetic peptide directed towards the N terminal region of human DGCR8
- Top Product
- Discover our top product DGCR8 Anticorps primaire
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- Indications d'application
- Optimal working dilutions should be determined experimentally by the investigator.
- Commentaires
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Antigen size: 773 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freeze-thaw cycles.
- Stock
- -20 °C
- Stockage commentaire
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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DGCR8 is essential for tumor progression following PTEN loss in the prostate." dans: EMBO reports, Vol. 16, Issue 9, pp. 1219-32, (2015) (PubMed).
: "Localization and sub-cellular shuttling of HTLV-1 tax with the miRNA machinery." dans: PLoS ONE, Vol. 7, Issue 7, pp. e40662, (2012) (PubMed).
: "NMDA mediated contextual conditioning changes miRNA expression." dans: PLoS ONE, Vol. 6, Issue 9, pp. e24682, (2011) (PubMed).
: "
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DGCR8 is essential for tumor progression following PTEN loss in the prostate." dans: EMBO reports, Vol. 16, Issue 9, pp. 1219-32, (2015) (PubMed).
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- Antigène
- DGCR8 (DiGeorge Syndrome Critical Region Gene 8 (DGCR8))
- Autre désignation
- DGCR8 (DGCR8 Produits)
- Synonymes
- anticorps MGC78846, anticorps DGCR8, anticorps gy1, anticorps dgcrk6, anticorps C22orf12, anticorps DGCRK6, anticorps Gy1, anticorps pasha, anticorps D16H22S1742E, anticorps D16H22S788E, anticorps D16Wis2, anticorps N41, anticorps Vo59c07, anticorps si:ch211-106a19.4, anticorps wu:fc23f08, anticorps wu:fc38f06, anticorps DGCR8 microprocessor complex subunit L homeolog, anticorps DiGeorge syndrome critical region gene 8, anticorps DGCR8 microprocessor complex subunit, anticorps DGCR8, microprocessor complex subunit, anticorps microRNA 3618, anticorps dgcr8.L, anticorps DGCR8, anticorps dgcr8, anticorps Dgcr8, anticorps MIR3618
- Sujet
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DGCR8 contains 2 DRBM (double-stranded RNA-binding) domains and 1 WW domain. It may play a part in the etiology of the velocardiofacial/DiGeorge syndrome (VCFS/DGS), a developmental disorder characterized by structural and functional palate anomalies, conotruncal cardiac malformations, immunodeficiency, hypocalcemia, and typical facial anomalies.
Alias Symbols: C22orf12, DGCRK6, Gy1, pasha
Protein Interaction Partner: MEOX2, PYCRL, DROSHA, RAE1, MAPK1, PRMT1, ERH, CDKN2A, BMI1, SRPK2, SRPK1, CDT1, NAT10, PLEK2, RPRD2, MAPRE2, PRPF4, FLII, APP, CUL3, DDX17, HNRNPR, NCL, ILF3, HSPA8, HSPA5, HNRNPU, HNRNPH1, FUS, DHX9, DDX5,
Protein Size: 773 - Poids moléculaire
- 85 kDa
- ID gène
- 54487
- NCBI Accession
- NM_022720, NP_073557
- UniProt
- Q8WYQ5
- Pathways
- Regulatory RNA Pathways
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