MAT1A anticorps (C-Term)

N° du produit ABIN2776786

Détail du produit anti-MAT1A anticorps

Antigène: MAT1A (Methionine Adenosyltransferase I, alpha (MAT1A))

Épitope: C-Term

Reactivité: Humain, Souris, Rat, Chien, Lapin, Boeuf (Vache), Cobaye, Poisson zèbre (Danio rerio), Cheval

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MAT1A est non-conjugé

Application: Western Blotting (WB)

Séquence: VAKSLVKAGL CRRVLVQVSY AIGVAEPLSI SIFTYGTSQK TERELLDVVH

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 93%, Horse: 93%, Human: 100%, Mouse: 93%, Rabbit: 86%, Rat: 93%, Zebrafish: 79%

Attributs du produit: This is a rabbit polyclonal antibody against MAT1A. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Protein A purified

Immunogène: The immunogen is a synthetic peptide directed towards the C terminal region of human MAT1A

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 395 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-MAT1A (ABIN2776786)

Hu, Lausted, Yoo, Yan, Brightman, Chen, Wang, Bu, Hood: "Quantitative liver-specific protein fingerprint in blood: a signature for hepatotoxicity." dans: Theranostics, Vol. 4, Issue 2, pp. 215-28, (2014) (PubMed).

Détails sur MAT1A

Antigène: MAT1A (Methionine Adenosyltransferase I, alpha (MAT1A))

Autre désignation: MAT1A (MAT1A Produits)

Synonymes: anticorps MAT, anticorps MATA1, anticorps SAMS, anticorps SAMS1, anticorps AdoMet, anticorps SADE, anticorps SAS, anticorps AI046368, anticorps Ams, anticorps wu:fi35e01, anticorps zgc:55442, anticorps methionine adenosyltransferase 1A, anticorps methionine adenosyltransferase I, alpha, anticorps MAT1A, anticorps Mat1a, anticorps mat1a

Sujet: MAT1A catalyzes a two-step reaction that involves the transfer of the adenosyl moiety of ATP to methionine to form S-adenosylmethionine and tripolyphosphate, which is subsequently cleaved to PPi and Pi. S-adenosylmethionine is the source of methyl groups for most biological methylations. MAT1A is found as a homotetramer (MAT I) or a homodimer (MAT III) whereas a third form, MAT II (gamma), is encoded by the MAT2A gene. Mutations in its gene are associated with methionine adenosyltransferase deficiency.This gne encodes methionine adenosyltransferase I (alpha isoform), which catalyzes the formation of S-adenosylmethionine from methionine and ATP. Methionine adenosyltransferase deficiency is caused by recessive and dominant mutations, the latter identified in autosomal dominant persistant hypermethioninemia.
Alias Symbols: MAT, MATA1, SAMS, SAMS1
Protein Interaction Partner: MAT1A, UBC, IST1, MVK, MAT2A,
Protein Size: 395

Poids moléculaire: 44 kDa

ID gène: 4143

NCBI Accession: NM_000429, NP_000420

UniProt: Q00266

Pathways: Mitotic G1-G1/S Phases, M Phase, Ribonucleoside Biosynthetic Process, Methionine Biosynthetic Process