Uromodulin anticorps (C-Term)
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- Antigène Voir toutes Uromodulin (UMOD) Anticorps
- Uromodulin (UMOD)
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Épitope
- C-Term
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Reactivité
- Humain, Souris, Chien, Boeuf (Vache)
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp Uromodulin est non-conjugé
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Application
- Western Blotting (WB)
- Séquence
- PTCSGTRFRS GSVIDQSRVL NLGPITRKGV QATVSRAFSS LGLLKVWLPL
- Homologie
- Cow: 91%, Dog: 86%, Human: 100%, Mouse: 85%
- Attributs du produit
- This is a rabbit polyclonal antibody against UMOD. It was validated on Western Blot.
- Purification
- Affinity Purified
- Immunogène
- The immunogen is a synthetic peptide directed towards the C terminal region of human UMOD
- Top Product
- Discover our top product UMOD Anticorps primaire
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- Indications d'application
- Optimal working dilutions should be determined experimentally by the investigator.
- Commentaires
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Antigen size: 640 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freeze-thaw cycles.
- Stock
- -20 °C
- Stockage commentaire
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Antigène
- Uromodulin (UMOD)
- Autre désignation
- UMOD (UMOD Produits)
- Synonymes
- anticorps ADMCKD2, anticorps FJHN, anticorps HNFJ, anticorps HNFJ1, anticorps MCKD2, anticorps THGP, anticorps THP, anticorps urehr4, anticorps uromodulin, anticorps UMOD, anticorps Umod
- Sujet
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This gene encodes uromodulin, the most abundant protein in normal urine. Its excretion in urine follows proteolytic cleavage of the ectodomain of its glycosyl phosphatidylinosital-anchored counterpart that is situated on the luminal cell surface of the loop of Henle. Uromodulin may act as a constitutive inhibitor of calcium crystallization in renal fluids. Excretion of uromodulin in urine may provide defense against urinary tract infections caused by uropathogenic bacteria. Defects in this gene are associated with the autosomal dominant renal disorders medullary cystic kidney disease-2 (MCKD2) and familial juvenile hyperuricemic nephropathy (FJHN). These disorders are characterized by juvenile onset of hyperuricemia, gout, and progressive renal failure. While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same isoform.
Alias Symbols: ADMCKD2, FJHN, HNFJ, HNFJ1, MCKD2, THGP, THP
Protein Interaction Partner: LTA, MMP8,
Protein Size: 640 - Poids moléculaire
- 67 kDa
- ID gène
- 7369
- NCBI Accession
- NM_001008389, NP_001008390
- UniProt
- P07911
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