MUC1 anticorps (C-Term)

N° du produit ABIN2776819

Détail du produit anti-MUC1 anticorps

Antigène: MUC1 (Mucin 1 (MUC1))

Épitope: C-Term

Reactivité: Humain, Souris, Rat, Boeuf (Vache), Chien, Lapin, Cobaye, Cheval

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MUC1 est non-conjugé

Application: Immunohistochemistry (IHC), Western Blotting (WB)

Séquence: GQLDIFPARD TYHPMSEYPT YHTHGRYVPP SSTDRSPYEK VSAGNGGSSL

Homologie: Cow: 92%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%

Attributs du produit: This is a rabbit polyclonal antibody against MUC1. It was validated on Western Blot and immunohistochemistry.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the C terminal region of human MUC1

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 203 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur MUC1

Antigène: MUC1 (Mucin 1 (MUC1))

Autre désignation: MUC1 (MUC1 Produits)

Synonymes: anticorps CA 15-3, anticorps CD227, anticorps EMA, anticorps H23AG, anticorps KL-6, anticorps MAM6, anticorps MCKD1, anticorps MUC-1, anticorps MUC-1/SEC, anticorps MUC-1/X, anticorps MUC1/ZD, anticorps PEM, anticorps PEMT, anticorps PUM, anticorps Muc-1, anticorps mucin 1, cell surface associated, anticorps mucin 1, transmembrane, anticorps MUC1, anticorps Muc1

Sujet: MUC1 is a membrane bound, glycosylated phosphoprotein. The protein is anchored to the apical surface of many epithelia by a transmembrane domain, with the degree of glycosylation varying with cell type. It also includes a 20 aa variable number tandem repeat (VNTR) domain, with the number of repeats varying from 20 to 120 in different individuals. The protein serves a protective function by binding to pathogens and also functions in a cell signaling capacity. Overexpression, aberrant intracellular localization, and changes in glycosylation of this protein have been associated with carcinomas.
Alias Symbols: CD227, EMA, PEM, PUM, mucin, KL-6, MAM6, PEMT, H23AG, MUC-1, MUC-1/X, MUC1/ZD, MUC-1/SEC
Protein Interaction Partner: UBC, PPARG, IPO5, NUP62, EGFR, ABL1, SRC, JUN, TP53, TBP, IKBKG, TNFRSF1A, IKBKB, GRB2, ESR1, GALNT15, GALNT12, GALNT10, OSGEP, GSK3B, GALNT2, GALNT1, CTNND1, SIGLEC1, ERBB4, ERBB3, SOS1, PRKCD, ZAP70, APC, JUP, LYN, ERBB2, LCK, CTNNB1, GALNT4, BAX, CDKN1
Protein Size: 203

Poids moléculaire: 22 kDa

ID gène: 4582

NCBI Accession: NM_001044390, NP_001037855

UniProt: Q7Z552

Pathways: Negative Regulation of intrinsic apoptotic Signaling