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Vitamin D Receptor anticorps (N-Term)

VDR Reactivité: Humain WB Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN2776857
  • Antigène Voir toutes Vitamin D Receptor (VDR) Anticorps
    Vitamin D Receptor (VDR)
    Épitope
    • 15
    • 15
    • 13
    • 12
    • 7
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
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    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
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    N-Term
    Reactivité
    • 91
    • 56
    • 40
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 98
    • 11
    • 1
    • 1
    Lapin
    Clonalité
    • 92
    • 19
    Polyclonal
    Conjugué
    • 56
    • 6
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    Cet anticorp Vitamin D Receptor est non-conjugé
    Application
    • 85
    • 33
    • 26
    • 26
    • 15
    • 14
    • 13
    • 10
    • 6
    • 5
    • 4
    • 2
    • 2
    • 1
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    Western Blotting (WB)
    Séquence
    EAMAASTSLP DPGDFDRNVP RICGVCGDRA TGFHFNAMTC EGCKGFFRRS
    Homologie
    Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%
    Attributs du produit
    This is a rabbit polyclonal antibody against VDR. It was validated on Western Blot using a cell lysate as a positive control.
    Purification
    Affinity Purified
    Immunogène
    The immunogen is a synthetic peptide directed towards the N terminal region of human VDR
    Top Product
    Discover our top product VDR Anticorps primaire
  • Indications d'application
    Optimal working dilutions should be determined experimentally by the investigator.
    Commentaires

    Antigen size: 427 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Avoid repeated freeze-thaw cycles.
    Stock
    -20 °C
    Stockage commentaire
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Antigène
    Vitamin D Receptor (VDR)
    Autre désignation
    VDR (VDR Produits)
    Synonymes
    anticorps vdrbeta, anticorps vdr0, anticorps LOC100136219, anticorps NR1I1-B, anticorps gb:dq017633, anticorps vdr-b, anticorps Ci-VDR-b, anticorps VDR, anticorps LOC100221284, anticorps vdr-A, anticorps xVDR, anticorps Nr1i1, anticorps vdr, anticorps NR1I1, anticorps PPP1R163, anticorps vitamin D (1,25- dihydroxyvitamin D3) receptor, anticorps vitamin D receptor, anticorps vitamin D3 receptor A, anticorps vitamin D receptor b, anticorps nuclear receptor VDR-b, anticorps vitamin D (1,25- dihydroxyvitamin D3) receptor L homeolog, anticorps vitamin D (1,25-dihydroxyvitamin D3) receptor, anticorps vitamin D receptor a, anticorps vdr, anticorps vdr0, anticorps VDR, anticorps LOC100136219, anticorps vdrb, anticorps vdr-b, anticorps vdr.L, anticorps Vdr, anticorps vdra
    Classe de substances
    Chemical
    Sujet
    The nuclear hormone receptor for vitamin D3 also functions as a receptor for the secondary bile acid lithocholic acid. The receptor belongs to the family of trans-acting transcriptional regulatory factors and shows sequence similarity to the steroid and thyroid hormone receptors. Downstream targets of this nuclear hormone receptor are principally involved in mineral metabolism though the receptor regulates a variety of other metabolic pathways, such as those involved in the immune response and cancer. Mutations in this gene are associated with type II vitamin D-resistant rickets. A single nucleotide polymorphism in the initiation codon results in an alternate translation start site three codons downstream. Alternative splicing results in multiple transcript variants encoding the same protein.This gene encodes the nuclear hormone receptor for vitamin D3. This receptor also functions as a receptor for the secondary bile acid lithocholic acid. The receptor belongs to the family of trans-acting transcriptional regulatory factors and shows sequence similarity to the steroid and thyroid hormone receptors. Downstream targets of this nuclear hormone receptor are principally involved in mineral metabolism though the receptor regulates a variety of other metabolic pathways, such as those involved in the immune response and cancer. Mutations in this gene are associated with type II vitamin D-resistant rickets. A single nucleotide polymorphism in the initiation codon results in an alternate translation start site three codons downstream. Alternative splicing results in multiple transcript variants encoding the same protein.
    Alias Symbols: NR1I1
    Protein Interaction Partner: MED12, MED24, BAZ1B, SMARCA4, RXRA, MED1, NCOA2, NSD1, NCOA1, SRPK1, PTPN3, Hr, NKD2, MMRN2, CDCA7L, CXXC5, UBC, RXRB, PRKCSH, PRCP, CFH, CCND3, MYC, MXD1, BRCA1, PSMC5, NCOR1, SRC, NCOA6, PPP1CC, CDK11B, NR1H2, RXRG, CASC4, GABARAPL1, GABARAPL2, CLASRP,
    Protein Size: 427
    Poids moléculaire
    48 kDa
    ID gène
    7421
    NCBI Accession
    NM_000376, NP_000367
    UniProt
    P11473
    Pathways
    Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway
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