SOCS1 anticorps (Middle Region)
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- Antigène Voir toutes SOCS1 Anticorps
- SOCS1 (Suppressor of Cytokine Signaling 1 (SOCS1))
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Épitope
- Middle Region
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Reactivité
- Humain, Souris, Rat, Boeuf (Vache), Lapin, Chien, Cheval, Cobaye
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp SOCS1 est non-conjugé
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Application
- Western Blotting (WB)
- Séquence
- RQRNCFFALS VKMASGPTSI RVHFQAGRFH LDGSRESFDC LFELLEHYVA
- Homologie
- Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%
- Attributs du produit
- This is a rabbit polyclonal antibody against SOCS1. It was validated on Western Blot.
- Purification
- Affinity Purified
- Immunogène
- The immunogen is a synthetic peptide directed towards the middle region of human SOCS1
- Top Product
- Discover our top product SOCS1 Anticorps primaire
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- Indications d'application
- Optimal working dilutions should be determined experimentally by the investigator.
- Commentaires
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Antigen size: 211 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freeze-thaw cycles.
- Stock
- -20 °C
- Stockage commentaire
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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Poor stimulation of bovine dendritic cells by Mycobacterium bovis culture supernatant and surface extract is associated with decreased activation of ERK and NF-κB and higher expression of SOCS1 and 3." dans: Innate immunity, Vol. 26, Issue 6, pp. 537-546, (2020) (PubMed).
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Poor stimulation of bovine dendritic cells by Mycobacterium bovis culture supernatant and surface extract is associated with decreased activation of ERK and NF-κB and higher expression of SOCS1 and 3." dans: Innate immunity, Vol. 26, Issue 6, pp. 537-546, (2020) (PubMed).
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- Antigène
- SOCS1 (Suppressor of Cytokine Signaling 1 (SOCS1))
- Autre désignation
- SOCS1 (SOCS1 Produits)
- Synonymes
- anticorps socs1, anticorps zgc:91868, anticorps jab, anticorps cis1, anticorps ssi1, anticorps tip3, anticorps cish1, anticorps ssi-1, anticorps socs-1, anticorps SOCS1, anticorps LOC100228306, anticorps socs1b, anticorps CIS1, anticorps CISH1, anticorps JAB, anticorps SOCS-1, anticorps SSI-1, anticorps SSI1, anticorps TIP3, anticorps Cish1, anticorps Cish7, anticorps Socs-1, anticorps suppressor of cytokine signaling 1a, anticorps suppressor of cytokine signaling 1, anticorps suppressor of cytokine signaling 1 L homeolog, anticorps socs1a, anticorps socs1, anticorps SOCS1, anticorps socs1.L, anticorps Socs1
- Sujet
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SOCS1 is a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. SOCS1 functions downstream of cytokine receptors, and takes part in a negative feedback loop to attenuate cytokine signaling. Knockout studies in mice suggested the role of its gene as a modulator of IFN-gamma action, which is required for normal postnatal growth and survival.
Alias Symbols: CIS1, CISH1, JAB, SOCS-1, SSI-1, SSI1, TIP3
Protein Interaction Partner: CSF2RB, TCEB1, ERBB2, ABL1, CYTIP, gag, TP53, JAK2, ATR, ATM, JAK1, INSR, FGFR3, LCK, RASA1, PDCD1, IRS1, ETV6, DAB1, TIRAP, VHL, VAV1, TUBG1, RELA, MAP3K5, CLEC7A, PTPN11, TYK2, IRF3, IFNAR1, TCEB2, ALK, COMMD1, TRIM8, PIK3R2, GHR, IRS2, TEC, NCK1, VAV2,
Protein Size: 211 - Poids moléculaire
- 23 kDa
- ID gène
- 8651
- NCBI Accession
- NM_003745, NP_003736
- UniProt
- O15524
- Pathways
- Signalistation JAK/STAT, Interferon-gamma Pathway, Signalisation TLR, Response to Growth Hormone Stimulus
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