PAX2A anticorps (Middle Region)

N° du produit ABIN2777232

Détail du produit anti-PAX2A anticorps

Antigène: PAX2A (Paired Box Gene 2a (PAX2A))

Épitope: Middle Region

Reactivité: Humain, Souris, Rat, Poisson zèbre (Danio rerio), Boeuf (Vache), Chien, Lapin, Mouton, Cobaye, Cheval

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PAX2A est non-conjugé

Application: Western Blotting (WB)

Séquence: DPVGSYSING ILGIPRSNGE KRKRDEDVSE GSVPNGDSQS GVDSLRKHLR

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 93%, Rabbit: 100%, Rat: 100%, Sheep: 100%, Zebrafish: 100%

Attributs du produit: This is a rabbit polyclonal antibody against PAX2. It was validated on Western Blot.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of Human PAX2

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 393 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-PAX2A (ABIN2777232)

Palmieri, Gojis, Rudraraju, Stamp-Vincent, Wilson, Langdon, Gourley, Faratian: "Expression of steroid receptor coactivator 3 in ovarian epithelial cancer is a poor prognostic factor and a marker for platinum resistance." dans: British journal of cancer, Vol. 108, Issue 10, pp. 2039-44, (2013) (PubMed).

Viringipurampeer, Ferreira, DeMaria, Yoon, Shan, Moosajee, Gregory-Evans, Ngai, Gregory-Evans: "Pax2 regulates a fadd-dependent molecular switch that drives tissue fusion during eye development." dans: Human molecular genetics, Vol. 21, Issue 10, pp. 2357-69, (2012) (PubMed).

Lee, Doberstein, Baumgarten, Wieland, Ungerer, Bürger, Hardt, Boehncke, Pfeilschifter, Mihic-Probst, Mittelbronn, Gutwein: "PAX2 regulates ADAM10 expression and mediates anchorage-independent cell growth of melanoma cells." dans: PLoS ONE, Vol. 6, Issue 8, pp. e22312, (2011) (PubMed).

Yu, Moriniere, Birke, Neumann, Fuchshofer, Kampik, Bloemendal, Welge-Lussen: "Reactivation of optic nerve head astrocytes by TGF-beta2 and H2O2 is accompanied by increased Hsp32 and Hsp47 expression." dans: Investigative ophthalmology & visual science, Vol. 50, Issue 4, pp. 1707-17, (2009) (PubMed).

Hurtado, Holmes, Geistlinger, Hutcheson, Nicholson, Brown, Jiang, Howat, Ali, Carroll: "Regulation of ERBB2 by oestrogen receptor-PAX2 determines response to tamoxifen." dans: Nature, Vol. 456, Issue 7222, pp. 663-6, (2008) (PubMed).

Yu, Fuchshofer, Birke, Priglinger, Eibl, Kampik, Bloemendal, Welge-Lussen: "Hypoxia/reoxygenation and TGF-beta increase alphaB-crystallin expression in human optic nerve head astrocytes." dans: Experimental eye research, Vol. 84, Issue 4, pp. 694-706, (2007) (PubMed).

Détails sur PAX2A

Antigène: PAX2A (Paired Box Gene 2a (PAX2A))

Autre désignation: PAX2 (PAX2A Produits)

Synonymes: anticorps PAPRS, anticorps Opdc, anticorps Pax-2, anticorps Pax-2a, anticorps XPax-2, anticorps XPax2, anticorps pax-2, anticorps pax2, anticorps xPax-2a, anticorps PAXZF-B, anticorps cb378, anticorps noi, anticorps pax-b, anticorps pax2.1, anticorps pax2a1, anticorps pax[zf-b], anticorps paxb, anticorps pax2.2, anticorps paired box 2, anticorps paired box 2 L homeolog, anticorps paired box 2a, anticorps paired box 2b, anticorps PAX2, anticorps Pax2, anticorps pax2.L, anticorps pax2a, anticorps pax2b

Sujet: PAX2 encodes paired box gene 2, one of many human homologues of the Drosophila melanogaster gene prd. The central feature of this transcription factor gene family is the conserved DNA-binding paired box domain. PAX2 is believed to be a target of transcriptional supression by the tumor supressor gene WT1. Mutations within PAX2 have been shown to result in optic nerve colobomas and renal hypoplasia.
Alias Symbols: -
Protein Interaction Partner: BBS7, BBS4, BBS2, BBS1, RB1, BRCA1, SFRP2, PAXIP1, WT1, MAPK8IP1, MAPK8, ID2,
Protein Size: 393

Poids moléculaire: 42 kDa

ID gène: 5076

NCBI Accession: NM_000278, NP_000269

UniProt: Q02962

Pathways: Carbohydrate Homeostasis, Stem Cell Maintenance, Tube Formation